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Items where Division is "Institute for Cardiovascular and Metabolic Research (ICMR)" and Year is 2021

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Number of items: 34.

Article

Adiyaman, R. and McGuffin, L. orcid id iconORCID: https://orcid.org/0000-0003-4501-4767 (2021) ReFOLD3: refinement of 3D protein models with gradual restraints based on predicted local quality and residue contacts. Nucleic Acids Research, 49 (W1). W589-W596. ISSN 1362-4962 doi: 10.1093/nar/gkab300

Ahmad, F., Mitchell, R., Houben, T., Palo, A., Yasdati, T., Parnell, A., Patel, K., Shiri-Sverdlov, R. and Leake, D. orcid id iconORCID: https://orcid.org/0000-0002-1742-6134 (2021) Cysteamine decreases low density lipoprotein oxidation, causes regression of atherosclerosis and improves liver and muscle function in LDL receptor deficient mice. JAHA: Journal of the American Heart Association, 10 (18). ISSN 2047-9980 doi: 10.1161/JAHA.120.017524

Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Hoepel, W., Mitchell, J. L., Jegouic, S. M., Loureiro, S. orcid id iconORCID: https://orcid.org/0009-0000-8886-6893, Sage, T., Vidarsson, G., Nouta, J., Wuhrer, M., de Taeye, S. W., van Gils, M., Kriek, N., Cooper, N., Jones, I. orcid id iconORCID: https://orcid.org/0000-0002-7738-2516, den Dunnen, J. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2021) Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a pro-thrombotic stimulus for platelets. Blood, 138 (16). pp. 1481-1489. ISSN 0006-4971 doi: 10.1182/blood.2021011871

Cai, H., Sasikumar, P., Little, G., Bihan, D., Hamaia, S. W., Zhou, A., Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 and Farndale, R. W. (2021) Identification of HSP47 binding site on native collagen and its implications on the development of HSP47 inhibitors. Biomolecules, 11 (7). 983. ISSN 2218-273X doi: 10.3390/biom11070983

Chamata, Y., Jackson, K. G. orcid id iconORCID: https://orcid.org/0000-0002-0070-3203, Watson, K. A. orcid id iconORCID: https://orcid.org/0000-0002-9987-8539 and Jauregi, P. (2021) Whey-derived peptides at the heart of the COVID-19 pandemic. International Journal of Molecular Sciences, 22 (21). 11662. ISSN 1422-0067 doi: 10.3390/ijms222111662

Derrick, D. J. A., Wolton, K., Currie, R. A. and Tindall, M. J. (2021) A mathematical model of the role of aggregation in sonic hedgehog signalling. PLoS computational biology, 17 (2). e1008562. ISSN 1553-7358 doi: 10.1371/journal.pcbi.1008562

Dunster, J. orcid id iconORCID: https://orcid.org/0000-0001-8986-4902, Bye, A. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Kriek, N., Sage, T., Mitchell, J., Kempster, C., Batista, J., KcKinney, H., Thomas, P., Jones, C. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509, Downes, K., Unsworth, A. and Gibbins, J. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2021) Multi-parameter phenotyping of platelet reactivity for stratification of human cohorts. Blood Advances, 5 (20). pp. 4017-4030. ISSN 2473-9529 doi: 10.1182/bloodadvances.2020003261

Fernández, D. I. orcid id iconORCID: https://orcid.org/0000-0002-5055-9019, Provenzale, I., Cheung, H. Y. F., van Groningen, J., Tullemans, B. M. E., Veninga, A., Dunster, J. L. orcid id iconORCID: https://orcid.org/0000-0001-8986-4902, Honarnejad, S. orcid id iconORCID: https://orcid.org/0000-0002-4558-501X, van den Hurk, H., Kuijpers, M. J. E. and Heemskerk, J. W. M. (2021) Ultra-high throughput Ca2+ assay in platelets to distinguish ITAM-linked and G-protein coupled receptor activation. iScience, 25 (1). 103718. ISSN 2589-0042 doi: 10.1016/j.isci.2021.103718

Fuller, S. J., Edmunds, N. S., McGuffin, L. J. orcid id iconORCID: https://orcid.org/0000-0003-4501-4767, Hardyman, M. A., Cull, J. J., Alharbi, H. O., Meijles, D. N., Sugden, P. H. and Clerk, A. orcid id iconORCID: https://orcid.org/0000-0002-5658-0708 (2021) MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins. Biochemical Journal, 478 (11). pp. 2121-2143. ISSN 0264-6021 doi: 10.1042/BCJ20210003

Gaspar, R. S., Ferreira, P., Mitchell, J. L., Pula, G. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2021) Platelet-derived extracellular vesicles express NADPH oxidase-1 (Nox-1), generate superoxide and modulate platelet function. Free Radical Biology and Medicine, 165. pp. 395-400. ISSN 0891-5849 doi: 10.1016/j.freeradbiomed.2021.01.051

Gaspar, R. S., Mansilla, S., Vieira, V. A., da Silva, L. B., Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352, Castro, L., Trostchansky, A. and de A. Paes, A. M. (2021) The protein disulphide isomerase inhibitor CxxCpep modulates oxidative burst and mitochondrial function in platelets. Free Radical Biology and Medicine, 172. pp. 668-674. ISSN 0891-5849 doi: 10.1016/j.freeradbiomed.2021.07.011

Griffin, B. A. and Lovegrove, J. A. orcid id iconORCID: https://orcid.org/0000-0001-7633-9455 (2021) Evidence for beneficial associations between isoenergetic macronutrient exchanges and serum non-HDL cholesterol, a measure of all circulating atherogenic, apoB-containing lipoproteins. Journal of Nutrition, 151 (8). pp. 2096-2098. ISSN 1541-6100 doi: 10.1093/jn/nxab127

Griffin, B. A., Mensink, R. P. and Lovegrove, J. A. orcid id iconORCID: https://orcid.org/0000-0001-7633-9455 (2021) Does variation in serum LDL-cholesterol response to dietary fatty acids help explain the controversy over fat quality and cardiovascular disease risk? Atherosclerosis, 328. pp. 108-113. ISSN 0021-9150 doi: 10.1016/j.atherosclerosis.2021.03.024

Holbrook, L.-M., Keeton, S. J., Sasikumar, P., Nock, S., Gelzinis, J., Brunt, E., Ryan, S., Pantos, M. M., Verbetsky, C. A., Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 and Kennedy, D. R. (2021) Zafirlukast is a broad-spectrum thiol isomerase inhibitor that inhibits thrombosis without altering bleeding times. British Journal of Pharmacology, 178 (3). pp. 550-563. ISSN 1476-5381 doi: 10.1111/bph.15291

Houben, T., Yadati, T., De Kruijf, R., Gijbels, M. J., Luiken, J., Van Zandvoort, M., Kapsokalyvas, D., Lütjohann, D., Westerterp, M., Plat, J., Leake, D. orcid id iconORCID: https://orcid.org/0000-0002-1742-6134 and Shiri-Sverdlov, R. (2021) Pro-inflammatory implications of 2-hydroxypropyl-β-cyclodextrin treatment. Frontiers in Immunology, 12. 716357. ISSN 1664-3224 doi: 10.3389/fimmu.2021.716357

Jannah, N., Hadjiloucas, S. orcid id iconORCID: https://orcid.org/0000-0003-2380-6114 and Al-Malki, J. (2021) Arrhythmia detection using multi-lead ECG spectra and Complex Support Vector Machine classifiers. Procedia Computer Science, 194. pp. 69-79. ISSN 1877-0509 doi: 10.1016/j.procs.2021.10.060

Kryshtafovych, A. orcid id iconORCID: https://orcid.org/0000-0001-5066-7178, Moult, J. orcid id iconORCID: https://orcid.org/0000-0002-3012-2282, Billings, W. M., Della Corte, D. orcid id iconORCID: https://orcid.org/0000-0002-8884-9724, Fidelis, K. orcid id iconORCID: https://orcid.org/0000-0002-8061-412X, Kwon, S., Olechnovič, K. orcid id iconORCID: https://orcid.org/0000-0003-4918-9505, Seok, C. orcid id iconORCID: https://orcid.org/0000-0002-1419-9888, Venclovas, Č., Won, J., Adiyaman, R. and McGuffin, L. orcid id iconORCID: https://orcid.org/0000-0003-4501-4767 (2021) Modeling SARS‐CoV2 proteins in the CASP ‐commons experiment. Proteins: Structure, Function, and Bioinformatics, 89 (12). pp. 1987-1996. ISSN 0887-3585 doi: 10.1002/prot.26231

Livingstone, K. M., Celis-Morales, C., Navas-Carretero, S., San-Cristobal, R., Forster, H., Woolhead, C., O’Donovan, C. B., Moschonis, G., Manios, Y., Traczyk, I., Gundersen, T. E., Drevon, C. A., Marsaux, C. F. M., Fallaize, R., Macready, A. L. orcid id iconORCID: https://orcid.org/0000-0003-0368-9336, Daniel, H., Saris, W. H. M., Lovegrove, J. A. orcid id iconORCID: https://orcid.org/0000-0001-7633-9455, Gibney, M., Gibney, E. R., Walsh, M., Brennan, L., Martinez, J. A. and Mathers, J. C. (2021) Personalised nutrition advice reduces intake of discretionary foods and beverages: findings from the Food4Me randomised controlled trial. International Journal of Behavioral Nutrition and Physical Activity, 18 (1). 70. ISSN 1479-5868 doi: 10.1186/s12966-021-01136-5

Markey, O., Vasilopoulou, D., Kliem, K. E. orcid id iconORCID: https://orcid.org/0000-0002-0058-8225, Fagan, C. C. orcid id iconORCID: https://orcid.org/0000-0002-2101-8694, Grandison, A. S., Sutton, R., Humphries, D. J., Todd, S. orcid id iconORCID: https://orcid.org/0000-0002-9981-923X, Jackson, K. G. orcid id iconORCID: https://orcid.org/0000-0002-0070-3203, Givens, D. I. orcid id iconORCID: https://orcid.org/0000-0002-6754-6935 and Lovegrove, J. A. orcid id iconORCID: https://orcid.org/0000-0001-7633-9455 (2021) Postprandial fatty acid profile, but not cardiometabolic risk markers, is modulated by dairy fat manipulation in adults with moderate cardiovascular disease risk: the randomized controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) study. Journal of Nutrition, 151 (7). pp. 1755-1768. ISSN 1541-6100 doi: 10.1093/jn/nxab050

Navas-Carretero, S., San-Cristobal, R., Alvarez-Alvarez, I., Celis-Morales, C., Livingstone, K. M., O'Donovan, C. B., Mavrogianni, C., Lambrinou, C. P., Manios, Y., Traczyck, I., Drevon, C. A., Marsaux, C. F. M., Saris, W. H. M., Fallaize, R., Macready, A. L. orcid id iconORCID: https://orcid.org/0000-0003-0368-9336, Lovegrove, J. A. orcid id iconORCID: https://orcid.org/0000-0001-7633-9455, Gundersen, T. E., Walsh, M., Brennan, L., Gibney, E. R., Gibney, M., Mathers, J. C. and Martinez, J. A. (2021) Interactions of carbohydrate intake and physical activity with regulatory genes affecting glycaemia: a Food4Me study analysis. Lifestyle Genomics, 14 (3). pp. 63-72. ISSN 2504-3188 doi: 10.1159/000515068

Ojo, O. O. and Leake, D. S. orcid id iconORCID: https://orcid.org/0000-0002-1742-6134 (2021) Vitamins E and C do not effectively inhibit low density lipoprotein oxidation by ferritin at lysosomal pH. Free Radical Research, 55 (5). pp. 525-534. ISSN 1071-5762 doi: 10.1080/10715762.2021.1964494

Rathnayake, K. M., Weech, M. orcid id iconORCID: https://orcid.org/0000-0003-1738-877X, Lovegrove, J. A. orcid id iconORCID: https://orcid.org/0000-0001-7633-9455 and Jackson, K. G. orcid id iconORCID: https://orcid.org/0000-0002-0070-3203 (2021) Glu298Asp (rs1799983) polymorphism influences postprandial vascular reactivity and the insulin response to meals of varying fat composition in postmenopausal women: findings from the randomized, controlled DIVAS-2 study. Journal of Nutrition, 151 (4). pp. 848-856. ISSN 1541-6100 doi: 10.1093/jn/nxaa394

Sahli, K. A., Flora, G. D., Sasikumar, P., Maghrabi, A. H., Holbrook, L., AlOuda, S. K., Elgheznawy, A., Sage, T., Stainer, A. R., Adiyaman, R., AboHassan, M., Crescente, M., Kriek, N., Vaiyapuri, S. orcid id iconORCID: https://orcid.org/0000-0002-6006-6517, Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Unsworth, A. J., Jones, C. I. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509, McGuffin, L. J. orcid id iconORCID: https://orcid.org/0000-0003-4501-4767 and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2021) Structural, functional and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets. Blood, 137 (6). pp. 830-843. ISSN 0006-4971 doi: 10.1182/blood.2019004575

Simoes Gaspar, R. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2021) Thiol isomerases orchestrate thrombosis and haemostasis. Antioxidants & Redox Signaling, 35 (13). ISSN 1523-0864 doi: 10.1089/ars.2021.0086

Simoes Gaspar, R., Sage, T., Little, G., Kriek, N., Pula, G. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2021) Protein disulphide isomerase and NADPH oxidase 1 cooperate to control platelet function and are associated with cardiometabolic disease risk factors. Antioxidants, 10 (3). 497. ISSN 2076-3921 doi: 10.3390/antiox10030497

Taylor, K. A. orcid id iconORCID: https://orcid.org/0000-0002-4599-7727, Little, G. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2021) Mind the gap: connexins and pannexins in platelet function. Platelets, 32 (7). pp. 888-894. ISSN 0953-7104 doi: 10.1080/09537104.2021.1902971

Unsworth, A. J., Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Sage, T., Gaspar, R. S., Eaton, N., Drew, C., Stainer, A., Kriek, N., Volberding, P. J., Hutchinson, J. L., Riley, R., Jones, S., Mundell, S. J., Cui, W., Falet, H. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2021) Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling. Haematologica, 106 (7). ISSN 1592-8721 doi: 10.3324/haematol.2019.223529

Vavouraki, N. orcid id iconORCID: https://orcid.org/0000-0003-2581-4935, Tomkins, J. E. orcid id iconORCID: https://orcid.org/0000-0003-3010-6634, Kara, E. orcid id iconORCID: https://orcid.org/0000-0001-5428-6743, Houlden, H., Hardy, J., Tindall, M. J., Lewis, P. A. orcid id iconORCID: https://orcid.org/0000-0003-4537-0489 and Manzoni, C. (2021) Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias. iScience, 24 (5). 102484. ISSN 2589-0042 doi: 10.1016/j.isci.2021.102484

Vogtschmidt, Y. D., Raben, A., Faber, I., de Wilde, C., Lovegrove, J. A. orcid id iconORCID: https://orcid.org/0000-0001-7633-9455, Givens, D. I. orcid id iconORCID: https://orcid.org/0000-0002-6754-6935, Pfeiffer, A. F. H. and Soedamah-Muthu, S. S. (2021) Is protein the forgotten ingredient: effects of higher compared to lower protein diets on cardiometabolic risk factors. A systematic review and meta-analysis of randomised controlled trials. Atherosclerosis, 328. pp. 124-135. ISSN 0021-9150 doi: 10.1016/j.atherosclerosis.2021.05.011

Book or Report Section

Brackenridge, D. A. and McGuffin, L. J. orcid id iconORCID: https://orcid.org/0000-0003-4501-4767 (2021) Proteins and their interacting partners: an introduction to protein–ligand binding site prediction methods with a focus on FunFOLD3. In: Cacace, A. M., Hickey, C. M. and Bekes, M. (eds.) Targeted Protein Degradation: Methods and Protocols. Methods in Molecular Biology, 2365. Springer, pp. 43-58. ISBN 9781071616642 doi: 10.1007/978-1-0716-1665-9

Edmunds, N. S. and McGuffin, L. J. orcid id iconORCID: https://orcid.org/0000-0003-4501-4767 (2021) Computational methods for the elucidation of protein structure and interactions. In: Owens, R. J. (ed.) Methods Molecular Biology: Structural Proteomics. Methods Molecular Biology, 2305. Springer Nature, pp. 23-52. ISBN 9781071614068 doi: 10.1007/978-1-0716-1406-8_2

Thesis

Nock, S. (2021) The dual kinase and scaffold function of Btk downstream of GPVI and CLEC-2 in platelets. PhD thesis, University of Reading. doi: 10.48683/1926.00101688

Simões Gaspar, R. (2021) Investigation of how redox processes regulate platelet function in health and disease. PhD thesis, University of Reading. doi: 10.48683/1926.00107568

Sowa, M. A. (2021) Artificial lipid membranes to study the platelet CLEC-2-podoplanin interaction. PhD thesis, University of Reading. doi: 10.48683/1926.00109189

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