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Number of items: 36.

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Keovilay, J. A., Howard, K. C., Taylor, K. A. orcid id iconORCID: https://orcid.org/0000-0002-4599-7727, Khan, S., Wurl, S. E., Szahaj, M. K., Sage, T., Chandrika, N. T., Hou, C., Tsodikov, O. V., Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352, Garneau-Tsodikova, S. and Kennedy, D. R. (2025) Development of zafirlukast analogues for improved anti-thrombotic activity through thiol isomerase inhibition. Arteriosclerosis Thrombosis and Vascular Biology. ISSN 1524-4636 doi: 10.1161/ATVBAHA.124.321579

Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Kriek, N., Kempster, C., Dunster, J. L. orcid id iconORCID: https://orcid.org/0000-0001-8986-4902, Mitchell, J. L., Sage, T., Rawlings, S., Diaz Alonso, M. V., Shpakova, V. orcid id iconORCID: https://orcid.org/0000-0002-9304-7099, Whyte, A., Dymott, L., Mark, S., Brunton, M., Batista, J., McKinney, H., Thomas, P., Downes, K., Unsworth, A. J., Ruparelia, N., McKenna, C., Jones, C. I. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509 and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2025) TRIPLE score: GPVI and CD36 expression predict a prothrombotic platelet function phenotype. Circulation Research, 136 (4). pp. 439-441. ISSN 0009-7330 doi: 10.1161/CIRCRESAHA.124.325701

Mitchell, J. L., Dunster, J. L. orcid id iconORCID: https://orcid.org/0000-0001-8986-4902, Kriek, N., Unsworth, A. J., Sage, T., Mohammed, Y. M. M., De Simone, I., Taylor, K. A. orcid id iconORCID: https://orcid.org/0000-0002-4599-7727, Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Ólafsson, G., Brunton, M., Mark, S., Dymott, L. D., Whyte, A., Ruparelia, N., Mckenna, C., Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 and Jones, C. I. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509 (2023) The rate of platelet activation determines thrombus size and structure at arterial shear. Journal of Thrombosis and Haemostasis, 21 (8). pp. 2248-2259. ISSN 1538-7836 doi: 10.1016/j.jtha.2023.03.044

Mitchell, J. L., Little, G., Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Gaspar, R. S., Unsworth, A. J., Kriek, N., Sage, T., Stainer, A., Sangowawa, I., Morrow, G. B., Bastos, R. N., Shapiro, S., Desborough, M. J. R., Curry, N., Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352, Whyte, C. S., Mutch, N. J. and Jones, C. I. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509 (2023) Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability. Research and Practice in Thrombosis and Haemostasis, 7 (5). 100200. ISSN 2475-0379 doi: 10.1016/j.rpth.2023.100200

Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Kriek, N., Sage, T., Rawlings, S. J., Prodger, C., Kesavan, M., Lees, C., Booth, S., Cowen, L. G., Shefferd, K., Desborough, M. J., Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 and Eyre, T. A. (2023) Pirtobrutinib results in reversible platelet dysfunction compared to ibrutinib and acalabrutinib. Haematologica, 108 (5). ISSN 1592-8721 doi: 10.3324/haematol.2022.281402

Mitchell, J. L., Khan, D., Rana, R. H., Kriek, N., Unsworth, A. J., Sage, T., Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Laffan, M., Shapiro, S., Thakurta, A., Grech, H., Ramasamy, K. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2023) Multiple myeloma and its treatment contribute to increased platelet reactivity. Platelets, 34 (1). 2264940. ISSN 1369-1635 doi: 10.1080/09537104.2023.2264940

Kriek, N., Nock, S. H., Sage, T., Khalifa, B., Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Mitchell, J. L., Thomson, S., McLaughlin, M. G., Jones, S., Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 and Unsworth, A. J. orcid id iconORCID: https://orcid.org/0000-0003-3809-5984 (2022) Cucurbitacins elicit anti-platelet activity via perturbation of the cytoskeleton and integrin function. Thrombosis and Haemostasis, 122 (07). pp. 1115-1129. ISSN 0340-6245 doi: 10.1055/a-1788-5322

Kempster, C., Butler, G., Kuznecova, E., Taylor, K. A. orcid id iconORCID: https://orcid.org/0000-0002-4599-7727, Kriek, N., Little, G., Sowa, M. A., Sage, T., Johnson, L. J. orcid id iconORCID: https://orcid.org/0000-0002-0006-1511, Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 and Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154 (2022) Fully automated platelet differential interference contrast image analysis via deep learning. Scientific Reports, 12. 4614. ISSN 2045-2322 doi: 10.1038/s41598-022-08613-2

Dunster, J. orcid id iconORCID: https://orcid.org/0000-0001-8986-4902, Bye, A. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Kriek, N., Sage, T., Mitchell, J., Kempster, C., Batista, J., KcKinney, H., Thomas, P., Jones, C. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509, Downes, K., Unsworth, A. and Gibbins, J. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2021) Multi-parameter phenotyping of platelet reactivity for stratification of human cohorts. Blood Advances, 5 (20). pp. 4017-4030. ISSN 2473-9529 doi: 10.1182/bloodadvances.2020003261

Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Hoepel, W., Mitchell, J. L., Jegouic, S. M., Loureiro, S. orcid id iconORCID: https://orcid.org/0009-0000-8886-6893, Sage, T., Vidarsson, G., Nouta, J., Wuhrer, M., de Taeye, S. W., van Gils, M., Kriek, N., Cooper, N., Jones, I. orcid id iconORCID: https://orcid.org/0000-0002-7738-2516, den Dunnen, J. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2021) Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a pro-thrombotic stimulus for platelets. Blood, 138 (16). pp. 1481-1489. ISSN 0006-4971 doi: 10.1182/blood.2021011871

Unsworth, A. J., Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Sage, T., Gaspar, R. S., Eaton, N., Drew, C., Stainer, A., Kriek, N., Volberding, P. J., Hutchinson, J. L., Riley, R., Jones, S., Mundell, S. J., Cui, W., Falet, H. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2021) Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling. Haematologica, 106 (7). ISSN 1592-8721 doi: 10.3324/haematol.2019.223529

Simoes Gaspar, R., Sage, T., Little, G., Kriek, N., Pula, G. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2021) Protein disulphide isomerase and NADPH oxidase 1 cooperate to control platelet function and are associated with cardiometabolic disease risk factors. Antioxidants, 10 (3). 497. ISSN 2076-3921 doi: 10.3390/antiox10030497

Sahli, K. A., Flora, G. D., Sasikumar, P., Maghrabi, A. H., Holbrook, L., AlOuda, S. K., Elgheznawy, A., Sage, T., Stainer, A. R., Adiyaman, R., AboHassan, M., Crescente, M., Kriek, N., Vaiyapuri, S. orcid id iconORCID: https://orcid.org/0000-0002-6006-6517, Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Unsworth, A. J., Jones, C. I. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509, McGuffin, L. J. orcid id iconORCID: https://orcid.org/0000-0003-4501-4767 and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2021) Structural, functional and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets. Blood, 137 (6). pp. 830-843. ISSN 0006-4971 doi: 10.1182/blood.2019004575

Gaspar, R. S., Unsworth, A. J., Al-Dibouni, A., Bye, A. P., Sage, T., Stewart, M., Cox, R. D., Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352, Sellayah, D. and Hughes, C. orcid id iconORCID: https://orcid.org/0000-0002-9790-5820 (2021) Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring. Scientific Reports, 11. 1473. ISSN 2045-2322 doi: 10.1038/s41598-020-80373-3

Dunster, J. L. orcid id iconORCID: https://orcid.org/0000-0001-8986-4902, Unsworth, A. J., Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Haining, E. J.,, Sowa, M. A., Di, Y., Sage, T., Pallini, C., Pike, J. A., Hardy, A. T., Nieswandt, B., García, Á., Watson, S. P., Poulter, N. S., Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 and Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154 (2020) Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation. Journal of Thrombosis and Haemostasis, 18 (2). pp. 485-496. ISSN 1538-7836 doi: 10.1111/jth.14673

Flora, G. D., Sahli, K. A., Sasikumar, P., Holbrook, L.-M., Stainer, A. R., Alouda, S. K., Crescente, M., Sage, T., Unsworth, A. J. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2019) Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis. Scientific Reports, 9 (1). 17210. ISSN 2045-2322 doi: 10.1038/s41598-019-53218-x

Unsworth, A. J., Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Kriek, N., Sage, T., Osborne, A. A., Donaghy, D. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2019) Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction. Platelets, 30 (6). pp. 762-772. ISSN 0953-7104 doi: 10.1080/09537104.2018.1514107

Sasikumar, P., AlOuda, K. S., Kaiser, W. J., Holbrook, L. M., Kriek, N., Unsworth, A. J., Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Sage, T., Ushioda, R. W., Nagata, K., Farndale, R. W. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2018) The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and haemostasis. Journal of Thrombosis and Haemostasis, 16 (5). pp. 946-959. ISSN 1538-7933 doi: 10.1111/jth.13998

Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Unsworth, A. J., Desborough, M. J., Hildyard, C. A. T., Appleby, N., Bruce, D., Kriek, N., Nock, S. H., Sage, T., Hughes, C. E. orcid id iconORCID: https://orcid.org/0000-0002-9790-5820 and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2017) Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib. Blood Advances, 1 (26). pp. 2610-2623. ISSN 2473-9529 doi: 10.1182/bloodadvances.2017011999

Unsworth, A. J., Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Tannetta, D. S., Desborough, M. J. R., Kriek, N., Sage, T., Allan, H. E., Crescente, M., Yaqoob, P. orcid id iconORCID: https://orcid.org/0000-0002-6716-7599, Warner, T. D., Jones, C. I. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509 and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2017) Farnesoid X receptor and liver X receptor ligands initiate formation of coated platelets. Arteriosclerosis, thrombosis, and vascular biology, 37 (8). pp. 1482-1493. ISSN 1524-4636 doi: 10.1161/ATVBAHA.117.309135

Unsworth, A. J., Flora, G. D., Sasikumar, P., Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Sage, T., Kriek, N., Crescente, M. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2017) RXR ligands negatively regulate thrombosis and hemostasis. Arteriosclerosis Thrombosis and Vascular Biology, 37 (5). pp. 812-822. ISSN 1524-4636 doi: 10.1161/ATVBAHA.117.309207

Unsworth, A. J., Kriek, N., Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Naran, K., Sage, T., Flora, G. D. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2017) PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signalling and platelet function through upregulation of protein kinase A activity. Journal of Thrombosis and Haemostasis, 15 (2). pp. 356-369. ISSN 1538-7933 doi: 10.1111/jth.13578

Moraes, L. A., Unsworth, A. J., Vaiyapuri, S. orcid id iconORCID: https://orcid.org/0000-0002-6006-6517, Ali, M. S., Sasikumar, P., Sage, T., Flora, G. D., Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Kriek, N., Dorchies, E., Molendi-Coste, O., Dombrowicz, D., Staels, B., Bishop-Bailey, D. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2016) Farnesoid X Receptor and its ligands inhibit the function of platelets. Arteriosclerosis Thrombosis and Vascular Biology, 36 (12). pp. 2324-2333. ISSN 1524-4636 doi: 10.1161/ATVBAHA.116.308093

Vaiyapuri, S. orcid id iconORCID: https://orcid.org/0000-0002-6006-6517, Sage, T., Rana, R. H., Schenk, M. P., Ali, M. S., Unsworth, A. J., Jones, C. I. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509, Stainer, A. R., Kriek, N. K., Moraes, L. A. and Gibbins, J. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2015) EphB2 regulates contact-dependent and independent signalling to control platelet function. Blood, 125 (4). pp. 720-730. ISSN 0006-4971 doi: 10.1182/blood-2014-06-585083

Jones, C. I. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509, Sage, T., Moraes, L. A., Vaiyapuri, S. orcid id iconORCID: https://orcid.org/0000-0002-6006-6517, Hussain, U., Tucker, K. L., Barrett, N. E. orcid id iconORCID: https://orcid.org/0000-0001-9123-1100 and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2014) Platelet endothelial cell adhesion molecule-1 inhibits platelet response to thrombin and von Willebrand factor by regulating the internalization of glycoprotein Ib via AKT/glycogen synthase kinase-3/dynamin and integrin αIIbβ3. Arteriosclerosis Thrombosis and Vascular Biology, 34 (9). pp. 1968-1976. ISSN 1079-5642 doi: 10.1161/ATVBAHA.114.304097

Jones, C. I. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509, Tucker, K. L., Sasikumar, P., Sage, T., Kaiser, W. J., Moore, C., Emerson, M. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2014) Integrin-linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi. Journal of Thrombosis and Haemostasis, 12 (8). pp. 1342-1352. ISSN 1538-7933 doi: 10.1111/jth.12620

Waller, A. K., Sage, T., Kumar, C., Carr, T., Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 and Clarke, S. R. (2013) Staphylococcus aureus lipoteichoic acid inhibits platelet activation and thrombus formation via the Paf receptor. Journal of Infectious Diseases, 208 (12). pp. 2046-2057. ISSN 1537-6613 doi: 10.1093/infdis/jit398

Vaiyapuri, S. orcid id iconORCID: https://orcid.org/0000-0002-6006-6517, Ali, M. S., Moraes, L. A., Sage, T., Lewis, K. R., Jones, C. I. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509 and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2013) Tangeretin regulates platelet function through inhibition of phosphoinositide 3-Kinase and cyclic nucleotide signaling. Arteriosclerosis Thrombosis and Vascular Biology, 33 (12). pp. 2740-2749. ISSN 1079-5642 doi: 10.1161/ATVBAHA.113.301988

Moraes, L. A., Vaiyapuri, S. orcid id iconORCID: https://orcid.org/0000-0002-6006-6517, Sasikumar, P., Ali, M. S., Kriek, N. K., Sage, T. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2013) Antithrombotic actions of statins involve PECAM-1 signalling. Blood, 122 (18). pp. 3188-3196. ISSN 0006-4971 doi: 10.1182/blood-2013-04-491845

Vaiyapuri, S. orcid id iconORCID: https://orcid.org/0000-0002-6006-6517, Moraes, L. A., Sage, T., Ali, M. S., Lewis, K. R., Mayhaut-Smith, M. P., Oviedo-Orta, E., Simon, A. M. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2013) Connexin40 regulates platelet function. Nature Communications, 4. pp. 2564-2572. ISSN 2041-1723 doi: 10.1038/ncomms3564

Vaiyapuri, S. orcid id iconORCID: https://orcid.org/0000-0002-6006-6517, Jones, C. I. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509, Sasikumar, P., Moraes, L. A., Munger, S. J., Wright, J. R., Ali, M. S., Sage, T., Kaiser, W. J., Tucker, K. L., Stain, C. J., Bye, A. P., Jones, S., Oviedo-Orta, E., Simon, A. M., Mahaut-Smith, M. P. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2012) Gap junctions and connexin hemichannels underpin hemostasis and thrombosis. Circulation, 125 (20). pp. 2479-2491. ISSN 0009-7322 doi: 10.1161/CIRCULATIONAHA.112.101246

Spyridon, M., Moraes, L. A., Jones, C. I. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509, Sage, T., Sasikumar, P., Bucci, G. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2011) LXR as a novel antithrombotic target. Blood, 117 (21). pp. 5751-5761. ISSN 1528-0020 doi: 10.1182/blood-2010-09-306142

Moraes, L. A., Barrett, N. E. orcid id iconORCID: https://orcid.org/0000-0001-9123-1100, Jones, C. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509, Holbrook, L. M., Spyridon, M., Sage, T., Newman, D. K. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2010) Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells. Journal of Thrombosis and Haemostasis, 8 (11). pp. 2530-2541. ISSN 1538-7933 doi: 10.1111/j.1538-7836.2010.04025.x

Moraes, L. A., Spyridon, M., Kaiser, W. J., Jones, C. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509, Sage, T., Atherton, R. E. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2010) Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation. Journal of Thrombosis and Haemostasis, 8 (3). pp. 577-587. ISSN 1538-7933 doi: 10.1111/j.1538-7836.2009.03732.x

Cicmil, M., Thomas, J. M., Sage, T., Barry, F. A., Leduc, M., Bon, C. and Gibbins, J. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2000) Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases. The Journal of biological chemistry, 275 (35). pp. 27339-27347. ISSN 0021-9258 doi: 10.1074/jbc.M003196200

Book or Report Section

Tucker, K. L., Sage, T. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2011) Clot retraction. In: Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 and Mahaut-Smith, M. P. (eds.) Platelets and Megakaryocytes. vol. 3, Additional Protocols and Perspectives. Methods in Molecular Biology, vol. 788. Humana Press, pp. 101-108. ISBN 9781617793066

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