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Sowa, M., Wu, Y. orcid id iconORCID: https://orcid.org/0000-0002-0470-4908, van Groningen, J., Di, Y., van den Hurk, H., Eble, J., Gibbins, J. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352, Garcia, Á. and Pollitt, A. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154 (2025) High-throughput screen identifies MAS9 as a novel inhibitor of the CLEC-2-Podoplanin interaction. British Journal of Pharmacology. ISSN 0007-1188 (In Press)

Castelletto, V. orcid id iconORCID: https://orcid.org/0000-0002-3705-0162, Seitsonen, J., Pollitt, A. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154 and Hamley, I. W. orcid id iconORCID: https://orcid.org/0000-0002-4549-0926 (2024) Minimal peptide sequences that undergo liquid–liquid phase separation via self-coacervation or complex coacervation with ATP. Biomacromolecules. ISSN 1526-4602 doi: 10.1021/acs.biomac.4c00738

Ma, J., Xie, R., Ayyadhury, S., Ge, C., Gupta, A., Gupta, R., Gu, S., Zhang, Y., Lee, G., Kim, J., Lou, W., Li, H., Upschulte, E., Dickscheid, T., de Almeida, J., Wang, Y., Han, L., Yang, X., Labagnara, M., Gligorovski, V., Scheder, M., Rahi, S., Kempster, C., Pollitt, A. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Espinosa, L., Mignot, Y., Middeke, J., Eckardt, J.-N., Li, W., Li, Z., Cai, X., Bai, B., Greenwald, N., Van Valen, D., Weisbart, E., Cimini, B., Cheung, T., Bruck, O., Bader, G. and Wang, B. (2024) The multimodality cell segmentation challenge: towards universal solutions. Nature Methods. ISSN 1548-7105 doi: 10.1038/s41592-024-02233-6

Kenny, M., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Patil, S., Hiebner, D. W., Smolenski, A., Lakic, N., Fisher, R., Alsufyani, R., Lickert, S., Vogel, V. and Schoen, I. (2024) Contractility defects hinder glycoprotein VI-mediated platelet activation and affect platelet functions beyond clot contraction. Research and Practice in Thrombosis and Haemostasis, 8 (1). 102322. ISSN 2475-0379 doi: 10.1016/j.rpth.2024.102322

AlOuda, S. K., Sasikumar, P., AlThunayan, T., Alaajam, F., Khan, S., Sahli, K. A., Abohassan, M. S., Pollitt, A. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Jung, S. M. and Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 (2023) Role of heat shock protein 47 in platelet glycoprotein VI dimerisation and signaling. Research and Practice in Thrombosis and Haemostasis, 7 (6). 102177. ISSN 2475-0379 doi: 10.1016/j.rpth.2023.102177

Clark, J. C., Martin, E. M., Morán, L. A., Di, Y., Wang, X., Zuidscherwoude, M., Brown, H. C., Kavanagh, D. M., Hummert, J., Eble, J. A., Nieswandt, B., Stegner, D., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Herten, D.-P., Tomlinson, M. G., García, A. and Watson, S. P. (2023) Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists. Communications Biology, 6 (1). 376. ISSN 2399-3642 doi: 10.1038/s42003-023-04766-6

Morán, L. A., Di, Y., Sowa, M. A., Hermida-Nogueira, L., Barrachina, M. N., Martin, E., Clark, J. C., Mize, T. H., Eble, J. A., Moreira, D., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Loza, M. I., Domínguez, E., Watson, S. P. and Garcia, Á. (2022) Katacine is a new ligand of CLEC-2 that acts as a platelet agonist. Thrombosis and haemostasis, 122 (8). pp. 1361-1368. ISSN 0340-6245 doi: 10.1055/a-1772-1069

Kempster, C., Butler, G., Kuznecova, E., Taylor, K. A. orcid id iconORCID: https://orcid.org/0000-0002-4599-7727, Kriek, N., Little, G., Sowa, M. A., Sage, T., Johnson, L. J. orcid id iconORCID: https://orcid.org/0000-0002-0006-1511, Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 and Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154 (2022) Fully automated platelet differential interference contrast image analysis via deep learning. Scientific Reports, 12. 4614. ISSN 2045-2322 doi: 10.1038/s41598-022-08613-2

Danson, A. E., McStea, A., Wang, L., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Martin-Fernandez, M. L., Moraes, I., Walsh, M. A., MacIntyre, S. and Watson, K. A. orcid id iconORCID: https://orcid.org/0000-0002-9987-8539 (2020) Super-resolution fluorescence microscopy reveals clustering behaviour of Chlamydia pneumoniae’s major outer membrane protein. Biology, 9 (10). 344. ISSN 2079-7737 doi: 10.3390/biology9100344

Dunster, J. L. orcid id iconORCID: https://orcid.org/0000-0001-8986-4902, Unsworth, A. J., Bye, A. P. orcid id iconORCID: https://orcid.org/0000-0002-2061-2253, Haining, E. J.,, Sowa, M. A., Di, Y., Sage, T., Pallini, C., Pike, J. A., Hardy, A. T., Nieswandt, B., García, Á., Watson, S. P., Poulter, N. S., Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 and Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154 (2020) Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation. Journal of Thrombosis and Haemostasis, 18 (2). pp. 485-496. ISSN 1538-7836 doi: 10.1111/jth.14673

Nicolson, P. L., Nock, S. H., Hinds, J., Garcia-Quintanilla, L., Smith, C. W., Campos, J., Brill, A., Pike, J. A., Khan, A. O., Poulter, N. S., Kavanagh, D. M., Watson, S., Watson, C. N., Clifford, H., Huissoon, A. P., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Eble, J. A., Pratt, G., Watson, S. P. and Hughes, C. E. orcid id iconORCID: https://orcid.org/0000-0002-9790-5820 (2020) Low dose Btk inhibitors selectively block platelet activation by CLEC-2. Haematologica, 105 (1). ISSN 1592-8721 doi: 10.3324/haematol.2019.218545

Nicolson, P. L. R., Hughes, C. E. orcid id iconORCID: https://orcid.org/0000-0002-9790-5820, Watson, S., Nock, S. H., Hardy, A. T., Watson, C. N., Montague, S. J., Clifford, H., Huissoon, A. P., Malcor, J.-D., Thomas, M. R., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Tomlinson, M. G., Pratt, G. and Watson, S. P. (2018) Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation to GPVI. Haematologica, 103 (12). pp. 2097-2108. ISSN 1592-8721 doi: 10.3324/haematol.2018.193391

Lombard, S. E., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Hughes, C. E. orcid id iconORCID: https://orcid.org/0000-0002-9790-5820, Di, Y., Mckinnon, T., O'Callaghan, C. A. and Watson, S. P. (2018) Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: a novel mechanism of haemostasis. Platelets, 29 (7). pp. 716-722. ISSN 0953-7104 doi: 10.1080/09537104.2017.1356919

Dustin, M. L. and Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154 (2018) The study of platelet receptors using artificial lipid bilayers. In: Gibbins, J. M. orcid id iconORCID: https://orcid.org/0000-0002-0372-5352 and Mahaut-Smith, M. (eds.) Platelets and Megakaryocytes: Volume 4, Advanced Protocols and Perspectives. Methods in Molecular Biology, 1812. Humana Press, New York, pp. 127-137. ISBN 9781493985845 doi: 10.1007/978-1-4939-8585-2_8

Poulter, N. S., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Owen, D. M., Gardiner, E. E., Andrews, R. K., Shimizu, H., Ishikawa, D., Bihan, D., Farndale, R. W., Moroi, M., Watson, S. P. and Jung, S. M. (2017) Clustering of GPVI dimers upon adhesion to collagen as a mechanism to regulate GPVI signalling in platelets. Journal of Thrombosis and Haemostasis, 15 (3). pp. 549-564. ISSN 1538-7933 doi: 10.1111/jth.13613

Alshehri, O. M., Montague, S., Watson, S., Carter, P., Sarker, N., Manne, B. K., Miller, J. L. C., Herr, A. B., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, O'Callaghan, C. A., Kunapuli, S., Arman, M., Hughes, C. E. orcid id iconORCID: https://orcid.org/0000-0002-9790-5820 and Watson, S. P. (2015) Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands. Biochemical Journal, 468 (3). pp. 459-473. ISSN 0264-6021 doi: 10.1042/BJ20150192

Poulter, N. S., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Davies, A., Malinova, D., Nash, G. B., Hannon, M. J., Pikramenou, Z., Rappoport, J. Z., Hartwig, J. H., Owen, D. M., Thrasher, A. J., Watson, S. P. and Thomas, S. G. (2015) Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex. Nature Communications, 6. 7254. ISSN 2041-1723 doi: 10.1038/ncomms8254

Navarro-Núñez, L., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Lowe, K., Latif, A., Nash, G. B. and Watson, S. P. (2015) Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling. Thrombosis and haemostasis, 113 (5). pp. 1109-1120. ISSN 0340-6245 doi: 10.1160/TH14-09-0762

Flierl, U., Nero, T. L., Lim, B., Arthur, J. F., Yao, Y., Jung, S. M., Gitz, E., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Zaldivia, M. T. K., Jandrot-Perrus, M., Schäfer, A., Nieswandt, B., Andrews, R. K., Parker, M. W., Gardiner, E. E. and Peter, K. (2015) Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators. The Journal of Experimental Medicine, 212 (2). pp. 129-137. ISSN 1540-9538 doi: 10.1084/jem.20140391

Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Poulter, N. S., Gitz, E., Navarro-Nuñez, L., Wang, Y.-J., Hughes, C. E. orcid id iconORCID: https://orcid.org/0000-0002-9790-5820, Thomas, S. G., Nieswandt, B., Douglas, M. R., Owen, D. M., Jackson, D. G., Dustin, M. L. and Watson, S. P. (2014) Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells. The Journal of Biological Chemistry, 289 (52). pp. 35695-35710. ISSN 1083-351X doi: 10.1074/jbc.M114.584284

Gitz, E., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Gitz-Francois, J. J., Alshehri, O., Mori, J., Montague, S., Nash, G. B., Douglas, M. R., Gardiner, E. E., Andrews, R. K., Buckley, C. D., Harrison, P. and Watson, S. P. (2014) CLEC-2 expression is maintained on activated platelets and on platelet microparticles. Blood, 124 (14). pp. 2262-2270. ISSN 0006-4971 doi: 10.1182/blood-2014-05-572818

Borgognone, A., Navarro-Núñez, L., Correia, J. N., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Thomas, S. G., Eble, J. A., Pulcinelli, F. M., Madhani, M. and Watson, S. P. (2014) CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP. Journal of Thrombosis and Haemostasis, 12 (4). pp. 550-559. ISSN 1538-7933 doi: 10.1111/jth.12514

Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Hughes, C. E. orcid id iconORCID: https://orcid.org/0000-0002-9790-5820 and Watson, S. P. (2013) GPVI and CLEC-2. In: Michelson, A. D. (ed.) Platelets. 3rd edition. Academic Press, Amsterdam, pp. 215-231. ISBN 9780123878373 doi: 10.1016/B978-0-12-387837-3.00011-0

Ura, S., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Veltman, D. M., Morrice, N. A., Machesky, L. M. and Insall, R. H. (2012) Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation. Current Biology, 22 (7). pp. 553-561. ISSN 0960-9822 doi: 10.1016/j.cub.2012.02.020

Finney, B. A., Schweighoffer, E., Navarro-Núñez, L., Bénézech, C., Barone, F., Hughes, C. E. orcid id iconORCID: https://orcid.org/0000-0002-9790-5820, Langan, S. A., Lowe, K. L., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Mourao-Sa, D., Sheardown, S., Nash, G. B., Smithers, N., Reis e Sousa, C., Tybulewicz, V. L. J. and Watson, S. P. (2012) CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood, 119 (7). pp. 1747-1756. ISSN 0006-4971 doi: 10.1182/blood-2011-09-380709

Séverin, S., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Navarro-Nuñez, L., Nash, C. A., Mourão-Sá, D., Eble, J. A., Senis, Y. A. and Watson, S. P. (2011) Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signalling. The Journal of Biological Chemistry, 286 (6). pp. 4107-4116. ISSN 1083-351X doi: 10.1074/jbc.M110.167502

Hughes, C. E. orcid id iconORCID: https://orcid.org/0000-0002-9790-5820, Navarro-Núñez, L., Finney, B. A., Mourão-Sá, D., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154 and Watson, S. P. (2010) CLEC-2 is not required for platelet aggregation at arteriolar shear. Journal of Thrombosis and Haemostasis, 8 (10). pp. 2328-2332. ISSN 1538-7933 doi: 10.1111/j.1538-7836.2010.04006.x

Falet, H., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Begonja, A. J., Weber, S. E., Duerschmied, D., Wagner, D. D., Watson, S. P. and Hartwig, J. H. (2010) A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. The Journal of Experimental Medicine, 207 (9). pp. 1967-1979. ISSN 1540-9538 doi: 10.1084/jem.20100222

Watson, S. P., Herbert, J. M. J. and Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154 (2010) GPVI and CLEC-2 in hemostasis and vascular integrity. Journal of Thrombosis and Haemostasis, 8 (7). pp. 1456-1467. ISSN 1538-7933 doi: 10.1111/j.1538-7836.2010.03875.x

Hughes, C. E. orcid id iconORCID: https://orcid.org/0000-0002-9790-5820, Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Mori, J., Eble, J. A., Tomlinson, M. G., Hartwig, J. H., O'Callaghan, C. A., Fütterer, K. and Watson, S. P. (2010) CLEC-2 activates Syk through dimerization. Blood, 115 (14). pp. 2947-2955. ISSN 1528-0020 doi: 10.1182/blood-2009-08-237834

Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Grygielska, B., Leblond, B., Désiré, L., Eble, J. A. and Watson, S. P. (2010) Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac. Blood, 115 (14). pp. 2938-2946. ISSN 0006-4971 doi: 10.1182/blood-2009-12-257212

Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154 and Insall, R. H. (2009) WASP and SCAR/WAVE proteins: the drivers of actin assembly. Journal of cell science, 122 (Pt 15). pp. 2575-8. ISSN 0021-9533

Spalton, J. C., Mori, J., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Hughes, C. E. orcid id iconORCID: https://orcid.org/0000-0002-9790-5820, Eble, J. A. and Watson, S. P. (2009) The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets. Journal of thrombosis and haemostasis : JTH, 7 (7). pp. 1192-9. ISSN 1538-7836

Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154 and Insall, R. H. (2009) Loss of Dictyostelium HSPC300 causes a scar-like phenotype and loss of SCAR protein. BMC cell biology, 10. p. 13. ISSN 1471-2121

Christou, C. M., Pearce, A. C., Watson, A. A., Mistry, A. R., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Fenton-May, A. E., Johnson, L. A., Jackson, D. G., Watson, S. P. and O'Callaghan, C. A. (2008) Renal cells activate the platelet receptor CLEC-2 through podoplanin. The Biochemical journal, 411 (1). pp. 133-40. ISSN 1470-8728

Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154 and Insall, R. H. (2008) Abi mutants in Dictyostelium reveal specific roles for the SCAR/WAVE complex in cytokinesis. Current biology : CB, 18 (3). pp. 203-10. ISSN 0960-9822

Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Blagg, S. L., Ibarra, N. and Insall, R. H. (2006) Cell motility and SCAR localisation in axenically growing Dictyostelium cells. European journal of cell biology, 85 (9-10). pp. 1091-8. ISSN 0171-9335

Ibarra, N., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154 and Insall, R. H. (2005) Regulation of actin assembly by SCAR/WAVE proteins. Biochemical Society transactions, 33 (Pt 6). pp. 1243-6. ISSN 0300-5127

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