Long-lived excited-state dynamics of i-motif structures probed by time-resolved infrared spectroscopy

Keane, P. M., Baptista, F. R., Gurung, S. P., Devereux, S. J., Sazanovich, I. V., Towrie, M., Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995, Kelly, J. M. and Quinn, S. J. (2016) Long-lived excited-state dynamics of i-motif structures probed by time-resolved infrared spectroscopy. ChemPhysChem, 17 (9). pp. 1281-1287. ISSN 1439-7641 doi: 10.1002/cphc.201501183

Abstract/Summary

UV-generated excited states of cytosine (C) nucleobases are precursors to mutagenic photoproduct formation. The i-motif formed from C-rich sequences is known to exhibit high yields of long-lived excited states following UV absorption. Here the excited states of several i-motif structures have been characterized following 267 nm laser excitation using time-resolved infrared spectroscopy (TRIR). All structures possess a long-lived excited state of ~300 ps and notably in some cases decays greater than 1 ns are observed. These unusually long-lived lifetimes are attributed to the interdigitated DNA structure which prevents direct base stacking overlap.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/58037
Identification Number/DOI	10.1002/cphc.201501183
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Medicinal Chemistry Research Group
Publisher	Wiley
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