Items where Author is "Brazier, Dr John"

Article

Khater, M., Brazier, J. ORCID: https://orcid.org/0000-0002-4952-584X, Greco, F. and Osborn, H. ORCID: https://orcid.org/0000-0002-0683-0457 (2023) Anticancer evaluation of new organometallic ruthenium(II) flavone complexes. Medicinal Chemistry, 14 (2). pp. 253-267. ISSN 2632-8682 doi: 10.1039/D2MD00304J

Hutchins, M., Bovill, R. A., Stephens, P. J., Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X and Osborn, H. M. I. ORCID: https://orcid.org/0000-0002-0683-0457 (2022) Glycosides of nadifloxacin—synthesis and antibacterial activities against methicillin-resistant Staphylococcus aureus. Molecules, 27 (5). 1504. ISSN 1420-3049 doi: 10.3390/molecules27051504

Baptista, F. R., Devereux, S. J., Gurung, S. P., Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Sazanovich, I. V., Towrie, M., Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995, Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Kelly, J. M. and Quinn, S. J. (2020) The influence of loops on the binding of the [Ru(phen)2dppz]2+ light-switch compound to i-motif DNA structures revealed by time-resolved spectroscopy. Chemical Communications, 56 (67). pp. 9703-9706. ISSN 1359-7345 doi: 10.1039/D0CC03702H

Pages, B. J., Gurung, S. P., McQuaid, K. ORCID: https://orcid.org/0000-0002-3222-5584, Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 and Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X (2019) Stabilization of long-looped i-motif DNA by polypyridyl ruthenium complexes. Frontiers in Chemistry, 7. 744. ISSN 2296-2646 doi: 10.3389/fchem.2019.00744

McQuaid, K., Abell, H., Gurung, S. P., Allan, D. R., Winter, G., Sorensen, T., Cardin, D. J., Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 and Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378 (2019) Structural studies reveal the enantiospecific recognition of a DNA G-quadruplex by a ruthenium polypyridyl complex. Angewandte Chemie International Edition, 58 (29). pp. 9881-9885. ISSN 1433-7851 doi: 10.1002/anie.201814502

McQuaid, K., Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Cardin, D. J. and Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 (2018) X-ray crystal structures show DNA stacking advantage of terminal nitrile substitution in Ru-dppz complexes. Chemistry- A European Journal, 24 (59). pp. 15859-15867. ISSN 1521-3765 doi: 10.1002/chem.201803021

Takahashi, S., Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X and Sugimoto, N. (2017) Topological impact of noncanonical DNA structures on Klenow fragment of DNA polymerase. Proceedings of the National Academy of Sciences of the United States of America, 114 (36). pp. 9605-9610. ISSN 0027-8424 doi: 10.1073/pnas.1704258114

Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Gurung, S. P., Henle, J., Poidl, P., Andersson, J., Lincoln, P., Winter, G., Sorensen, T., Cardin, D. J., Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X and Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 (2017) Guanine can direct binding specificity of Ru-dppz complexes to DNA through steric effects. Chemistry: A European Journal, 23 (21). pp. 4981-4985. ISSN 0947-6539 doi: 10.1002/chem.201605508

Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Keane, P. M., Beer, H., Buchner, K., Winter, G., Sorensen, T. L., Cardin, D. J., Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X and Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 (2016) Delta chirality ruthenium ‘light-switch’ complexes can bind in the minor groove of DNA with five different binding modes. Nucleic Acids Research, 44 (19). pp. 9472-9482. ISSN 1362-4962 doi: 10.1093/nar/gkw753

Keane, P. M., Baptista, F. R., Gurung, S. P., Devereux, S. J., Sazanovich, I. V., Towrie, M., Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995, Kelly, J. M. and Quinn, S. J. (2016) Long-lived excited-state dynamics of i-motif structures probed by time-resolved infrared spectroscopy. ChemPhysChem, 17 (9). pp. 1281-1287. ISSN 1439-7641 doi: 10.1002/cphc.201501183

Parshotam, J. P., Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Bovill, R. and Osborn, H. M. I. ORCID: https://orcid.org/0000-0002-0683-0457 (2016) An efficient and rapid microwave-assisted synthesis of 1-acetyl-1H-indol-3-YL acetates. Current Microwave Chemistry, 3 (3). pp. 247-257. ISSN 2213-3364 doi: 10.2174/2213335603666160108001556

Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Poynton, F. E., Keane, P. M., Gurung, S. P., Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Cardin, D. J., Winter, G., Gunnlaugsson, T., Sazanovich, I. V., Towrie, M., Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995, Kelly, J. M. and Quinn, S. J. (2015) Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy. Nature Chemistry, 7. pp. 961-967. ISSN 1755-4330 doi: 10.1038/nchem.2369

Olorunniji, F. J., McPherson, A. L., Pavlou, H. J., McIlwraith, M. J., Brazier, J. ORCID: https://orcid.org/0000-0002-4952-584X, Cosstick, R. and Stark, W. M. (2015) Nicked-site substrates for a serine recombinase reveal enzyme–DNA communications and an essential tethering role of covalent enzyme–DNA linkages. Nucleic Acids Research, 43 (12). pp. 6134-6143. ISSN 1362-4962 doi: 10.1093/nar/gkv521

Kikuta, K., Piao, H., Brazier, J. ORCID: https://orcid.org/0000-0002-4952-584X, Taniguchi, Y., Onizuka, K., Nagatsugi, F. and Sasaki, S. (2015) Stabilization of the i-motif structure by the intra-strand cross-link formation. Bioorganic & Medicinal Chemistry Letters, 25 (16). pp. 3307-3310. ISSN 0960-894X doi: 10.1016/j.bmcl.2015.05.064

Gurung, S. P., Schwarz, C., Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 and Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X (2015) The importance of loop length on the stability of i-motif structures. Chemical Communications, 51 (26). pp. 5630-5632. ISSN 1359-7345 doi: 10.1039/C4CC07279K

Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Sanchez-Weatherby, J., Alberti, C., Hurtado Quimper, C., O'Sullivan, K., Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Winter, G., Sorensen, T., Kelly, J. M., Cardin, D. J. and Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 (2014) Controlled dehydration of a ruthenium complex-DNA crystal induces reversible DNA kinking. Journal of the American Chemical Society, 136 (50). pp. 17505-17512. ISSN 0002-7863 doi: 10.1021/ja508745x

Hall, J. P., Cook, D., Morte, S. R., McIntyre, P., Buchner, K., Beer, H., Cardin, D., Brazier, J. ORCID: https://orcid.org/0000-0002-4952-584X, Winter, G., Kelly, J. M. and Cardin, C. ORCID: https://orcid.org/0000-0002-2556-9995 (2013) X‑ray crystal structure of rac-[Ru(phen)2dppz]2+ with d(ATGCAT)2 shows enantiomer orientations and water ordering. Journal of the American Chemical Society, 135 (34). pp. 12652-12659. ISSN 0002-7863 doi: 10.1021/ja403590e

Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Shah, A. and Brown, G. D. (2012) I-Motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes. Chemical Communication, 48 (87). pp. 10739-10741. ISSN 1359-7345 doi: 10.1039/C2CC30863K

Jayakumar, H.K., Buckingham, J., Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Berry, N.G., Cosstick, R. and Fisher, J. (2007) NMR studies of the conformational effect of single and double 3'-S-phosphorothiolate substitutions within deoxythymidine trinucleotides. Magnetic Resonance in Chemistry, 45 (4). pp. 340-345. ISSN 1097-458X doi: 10.1002/mrc.1977

Bentley, J., Brazier, J. ORCID: https://orcid.org/0000-0002-4952-584X, Fisher, J. and Cosstick, R. (2007) Duplex stability of DNA.DNA and DNA.RNA duplexes containing 3 '-S-phosphorothiolate linkages. Organic & Biomolecular Chemistry, 5 (22). pp. 3698-3702. ISSN 1477-0520 doi: 10.1039/b713292a

Cosstick, R., Buckingham, J., Brazier, J. ORCID: https://orcid.org/0000-0002-4952-584X and Fisher, J. (2007) Stabilization of multi-stranded nucleic acid structures using 3'-S-phosphorothiolate linkages. Nucleosides Nucleotides & Nucleic Acids, 26 (6-7). pp. 555-558. ISSN 1525-7770 doi: 10.1080/15257770701490001

Gaynor, J. W., Brazier, J. ORCID: https://orcid.org/0000-0002-4952-584X and Cosstick, R. (2007) Synthesis of 3 '-S-phosphorothiolate oligonucleotides for their potential use in RNA interference. Nucleosides Nucleotides & Nucleic Acids, 26 (6-7). pp. 709-712. ISSN 1525-7770 doi: 10.1080/15257770701490753

Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Fisher, J. and Cosstick, R. (2006) Stabilization of the DNA I-motif structure by incorporation of 3 '-S-phosphorothiolate linkages. Angewandte Chemie-International Edition, 45 (1). pp. 114-117. ISSN 1521-3773 doi: 10.1002/anie.200503110

Shibata, T., Buurma, N. J., Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Thompson, P., Haq, I. and Williams, D. M. (2006) 7,8-dihydropyrido[2,3-d]pyrimidin-2-one; a bicyclic cytosine analogue capable of enhanced stabilisation of DNA duplexes. Chemical Communications (33). pp. 3516-3518. ISSN 1359-7345 doi: 10.1039/B606058G

Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Shibata, T., Townsley, J., Taylor, B. F., Frary, E., Williams, N. H. and Williams, D. M. (2005) Amino-functionalized DNA: the properties of C5-amino-alkyl substituted 2′-deoxyuridines and their application in DNA triplex formation. Nucleic Acids Research, 33 (4). pp. 1362-1371. ISSN 1362-4962 doi: 10.1093/nar/gki254

Lee, S.E., Sidorov, A., Gourlain, T., Mignet, N., Thorpe, S.J., Brazier, J.A. ORCID: https://orcid.org/0000-0002-4952-584X, Dickman, M.J., Hornby, D.P., Grasby, J.A. and Williams, D.M. (2001) Enhancing the catalytic repertoire of nucleic acids: a systematic study of linker length and rigidity. Nucleic Acids Research, 29 (7). pp. 1565-1573. ISSN 1362-4962 doi: 10.1093/nar/29.7.1565

Conference or Workshop Item

Roberts, J., Bowen, J., Brazier, J. ORCID: https://orcid.org/0000-0002-4952-584X, Lonnen, E. and Walker, G. (2014) Discerning the conformation of G-quadruplex forming DNA. In: 4th EOS Topical Meeting on Terahertz Science & Technology, 2014, Camogli, Italy.