Stabilization of multi-stranded nucleic acid structures using 3'-S-phosphorothiolate linkages

Cosstick, R., Buckingham, J., Brazier, J. ORCID: https://orcid.org/0000-0002-4952-584X and Fisher, J. (2007) Stabilization of multi-stranded nucleic acid structures using 3'-S-phosphorothiolate linkages. Nucleosides Nucleotides & Nucleic Acids, 26 (6-7). pp. 555-558. ISSN 1525-7770 doi: 10.1080/15257770701490001

Abstract/Summary

3 '-S-Phosphorothiolate linkages incorporated into an oligodeoxynucleotide have been shown to stabilise duplex formation with a complementary RNA strand, but destabilise a duplex formed with a complementary DNA strand. The four-stranded i-motif structure is also stabilised this modification.