7,8-dihydropyrido[2,3-d]pyrimidin-2-one; a bicyclic cytosine analogue capable of enhanced stabilisation of DNA duplexes

Shibata, T., Buurma, N. J., Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Thompson, P., Haq, I. and Williams, D. M. (2006) 7,8-dihydropyrido[2,3-d]pyrimidin-2-one; a bicyclic cytosine analogue capable of enhanced stabilisation of DNA duplexes. Chemical Communications (33). pp. 3516-3518. ISSN 1359-7345 doi: 10.1039/B606058G

Abstract/Summary

Incorporation of a bicyclic cytosine analogue, 3-beta-D-(2'-deoxyribofuranosyl)7,8- dihydropyrido[ 2,3-d] pyrimidine, into synthetic DNA duplexes results in a greatly enhanced thermal stability ( 3 - 4 degrees C per modification) compared to the corresponding unmodified duplex.