A mathematical model of the in vitro keratinocyte response to chromium and nickel exposure

Franks, S. J., Ward, J. P., Tindall, M. J., King, J. R., Curtis, A. and Evans, G. S. (2008) A mathematical model of the in vitro keratinocyte response to chromium and nickel exposure. Toxicol In Vitro, 22 (4). pp. 1088-93. ISSN 0887-2333 doi: 10.1016/j.tiv.2008.01.018

Abstract/Summary

A mathematical model describing the main mechanistic processes involved in keratinocyte response to chromium and nickel has been developed and compared to experimental in vitro data. Accounting for the interactions between the metal ions and the keratinocytes, the law of mass action was used to generate ordinary differential equations which predict the time evolution and ion concentration dependency of keratinocyte viability, the amount of metal associated with the keratinocytes and the release of cytokines by the keratinocytes. Good agreement between model predictions and existing experimental data of these endpoints was observed, supporting the use of this model to explore physiochemical parameters that influence the toxicological response of keratinocytes to these two metals.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/9789
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Biological Sciences
Uncontrolled Keywords	Chromium/*toxicity, Cytokines/drug effects/metabolism, Dermatitis, Contact/etiology, Humans, Keratinocytes/*drug effects/metabolism, *Models, Theoretical, Nickel/*toxicity, Occupational Exposure
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