Spatiotemporal modelling of CheY complexes in Escherichia coli chemotaxis

Tindall, M. J., Porter, S. L., Wadhams, G. H., Maini, P. K. and Armitage, J. P. (2009) Spatiotemporal modelling of CheY complexes in Escherichia coli chemotaxis. Progress in Biophysics & Molecular Biology, 100 (1-3). pp. 40-46. ISSN 0079-6107 doi: 10.1016/j.pbiomolbio.2009.06.005

Abstract/Summary

The chemotaxis pathway of Escherichia coli is one of the best studied and modelled biological signalling pathways. Here we extend existing modelling approaches by explicitly including a description of the formation and subcellular localization of intermediary complexes in the phosphotransfer pathway. The inclusion of these complexes shows that only about 60% of the total output response regulator (CheY) is uncomplexed at any moment and hence free to interact with its target, the flagellar motor. A clear strength of this model is its ability to predict the experimentally observable subcellular localization of CheY throughout a chemotactic response. We have found good agreement between the model output and experimentally determined CheY localization patterns. (C) 2009 Elsevier Ltd. All rights reserved.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/9710
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Biological Sciences
Uncontrolled Keywords	Bacterial chemotaxis, Phosphotransfer, Complex formation, Spatiotemporal mathematical modelling, Signal transduction, BACTERIAL CHEMOTAXIS, PHOSPHORYLATED CHEY, PROTEIN, BINDING, SENSITIVITY, COMPONENTS, CYTOPLASM, CELLS
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