Bilingualism is a long-term cognitively challenging experience that modulates metabolite concentrations in the healthy brain

[thumbnail of Open Access]
Preview
Text (Open Access) - Published Version
· Available under License Creative Commons Attribution.
· Please see our End User Agreement before downloading.
| Preview
Available under license: Creative Commons Attribution
[thumbnail of Pliatsikas et al., 2021_accepted.pdf]
Text - Accepted Version
· Restricted to Repository staff only
Restricted to Repository staff only

Please see our End User Agreement.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

Add to AnyAdd to TwitterAdd to FacebookAdd to LinkedinAdd to PinterestAdd to Email

Pliatsikas, C. orcid id iconORCID: https://orcid.org/0000-0001-7093-1773, Pereira Soares, S. M., Voits, T., DeLuca, V. and Rothman, J. (2021) Bilingualism is a long-term cognitively challenging experience that modulates metabolite concentrations in the healthy brain. Scientific Reports, 11 (1). 7090. ISSN 2045-2322 doi: 10.1038/s41598-021-86443-4

Abstract/Summary

Cognitively demanding experiences, including complex skills acquisition and processing, have been shown to induce brain adaptations, at least at the macroscopic level, e.g. on brain volume and/or functional connectivity. However, the neurobiological bases of these adaptations, including at the cellular level, are unclear and understudied. Here we use bilingualism as a case study to investigate the metabolic correlates of experience-based brain adaptations. We employ Magnetic Resonance Spectroscopy to measure metabolite concentrations in the basal ganglia, a region critical to language control and reshaped by bilingualism. Our results show increased myo-Inositol and decreased N-acetyl aspartate concentrations in bilinguals compared to monolinguals. Both metabolites are linked to synaptic pruning, a process underlying experience-based brain restructuring. Interestingly, both concentrations correlate with relative amount of bilingual engagement. This suggests that degree of long-term cognitive experiences matters at the level of metabolic concentrations, which might accompany, if not drive, macroscopic brain adaptations.

Altmetric Badge

Item Type Article
URI https://reading-clone.eprints-hosting.org/id/eprint/96898
Identification Number/DOI 10.1038/s41598-021-86443-4
Refereed Yes
Divisions Interdisciplinary Research Centres (IDRCs) > Centre for Literacy and Multilingualism (CeLM)
Interdisciplinary Research Centres (IDRCs) > Centre for Integrative Neuroscience and Neurodynamics (CINN)
Life Sciences > School of Psychology and Clinical Language Sciences > Neuroscience
Life Sciences > School of Psychology and Clinical Language Sciences > Department of Clinical Language Sciences
Life Sciences > School of Psychology and Clinical Language Sciences > Language and Cognition
Uncontrolled Keywords MRS, INS, NAA, Bilingualism
Publisher Scientific Reports
Download/View statistics View download statistics for this item

Downloads

Downloads per month over past year

University Staff: Request a correction | Centaur Editors: Update this record

Search Google Scholar