Rethinking the Citric Acid Cycle: connecting pyruvate carboxylase and citrate synthase to the flow of energy and material

Roosterman, D. and Cottrell, G. S. ORCID: https://orcid.org/0000-0001-9098-7627 (2021) Rethinking the Citric Acid Cycle: connecting pyruvate carboxylase and citrate synthase to the flow of energy and material. International Journal of Molecular Sciences, 22 (2). e604. ISSN 1422-0067 doi: 10.3390/ijms22020604

Abstract/Summary

In 1937, Sir H. A Krebs first published the Citric Acid Cycle, a unidirectional cycle with carboxylic acids. The original concept of the Citric Acid Cycle from Krebs’ 1953 Nobel Prize lecture illustrates the unidirectional degradation of lactic acid to water, carbon dioxide and hydrogen. Here, we add the heart lactate dehydrogenase•proton-linked monocarboxylate transporter 1 complex, connecting the original Citric Acid Cycle to the flow of energy and material. The heart lactate dehydrogenase•proton-linked monocarboxylate transporter 1 complex catalyses the first reaction of the Citric Acid Cycle, the oxidation of lactate to pyruvate, and thus secures the provision of pyruvic acid. In addition, we modify Krebs’ original concept by feeding the cycle with oxaloacetic acid. Our concept enables the integration of anabolic processes and allows adaption of the organism to recover ATP faster.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/95455
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Uncontrolled Keywords	Citric Acid Cycle, malic acid, succinic acid, oxidative phosphorylation, exercise, memory formation
Publisher	MDPI
Download/View statistics	View download statistics for this item