The double triangular test in practice

Whitehead, J. and Todd, S. ORCID: https://orcid.org/0000-0002-9981-923X (2004) The double triangular test in practice. Pharmaceutical Statistics, 3 (1). pp. 39-49. ISSN 1539-1612 doi: 10.1002/pst.91

Abstract/Summary

The double triangular test was introduced twenty years ago, and the purpose of this paper is to review applications that have been made since then. In fact, take-up of the method was rather slow until the late 1990s, but in recent years several clinical trial reports have been published describing its use in a wide range of therapeutic areas. The core of this paper is a detailed account of five trials that have been published since 2000 in which the method was applied to studies of pancreatic cancer, breast cancer, myocardial infarction, epilepsy and bedsores. Before those accounts are given, the method is described and the history behind its evolution is presented. The future potential of the method for sequential case-control and equivalence trials is also discussed. Copyright © 2004 John Wiley & Sons, Ltd.