Peptide nanotubes self-assembled from leucine-rich alpha helical surfactant-like peptides

Castelletto, V., Seitsonen, J., Ruokolainen, J., Piras, C., Cramer, R. ORCID: https://orcid.org/0000-0002-8037-2511, Edwards-Gayle, C. J. C. and Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926 (2020) Peptide nanotubes self-assembled from leucine-rich alpha helical surfactant-like peptides. Chemical Communications, 56 (80). pp. 11977-11980. ISSN 1359-7345 doi: 10.1039/D0CC04299D

Abstract/Summary

The designed arginine-rich surfactant-like peptide R3L12 (arginine3–leucine12) is shown to form a remarkable diversity of self-assembled nanostructures in aqueous solution, depending on pH, including nanotubes, mesh-like tubular networks in three-dimensions and square planar arrays in two-dimensions. These structures are built from α-helical antiparallel coiled–coil peptide dimers arranged perpendicular to the nanotube axis, in a “cross-α” nanotube structure. The aggregation behavior is rationalized based on the effects of dimensionality, and the balance of hydrophobic and electrostatic interactions. The nanotube and nanomesh structures display arginine at high density on their surfaces, which may be valuable for future applications.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/92606
Identification Number/DOI	10.1039/D0CC04299D
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Publisher	Royal Society of Chemistry
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