FTO gene-lifestyle interactions on serum adiponectin concentrations and central obesity in a Turkish population

Isgin-Atici, K., Alsulami, S., Turan-Demirci, B., Surendran, S., Sendur, S. N., Lay, I., Karabulut, E., Ellahi, B., Lovegrove, J. A. ORCID: https://orcid.org/0000-0001-7633-9455, Alikasifoglu, M., Erbas, T., Vimaleswaran, K. S. ORCID: https://orcid.org/0000-0002-8485-8930 and Buyuktuncer, Z. (2021) FTO gene-lifestyle interactions on serum adiponectin concentrations and central obesity in a Turkish population. International Journal of Food Sciences and Nutrition, 72 (1). pp. 375-385. ISSN 1465-3478 doi: 10.1080/09637486.2020.1802580

Abstract/Summary

The aim of the study was to investigate whether lifestyle factors modify the association fat mass and obesity-associated (FTO) gene single nucleotide polymorphisms (SNPs) and obesity in a Turkish population. The study included 400 unrelated individuals, aged 24-50 years recruited in a hospital setting. Dietary intake and physical activity were assessed using 24-hour dietary recall and self-report questionnaire, respectively. A genetic risk score (GRS) was developed using FTO SNPs, rs9939609 and rs10163409. Body mass index and fat mass index were significantly associated with FTO SNP rs9939609 (P=0.001 and P=0.002, respectively) and GRS (P=0.002 and P=0.003, respectively). The interactions between SNP rs9939609 and physical activity on adiponectin concentrations, and SNP rs10163409 and dietary protein intake on increased waist circumference were statistically significant (Pinteraction=0.027 and Pinteraction=0.044, respectively). This study demonstrated that the association between FTO SNPs and central obesity might be modified by lifestyle factors in this Turkish population.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/91931
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
Publisher	Informa Healthcare
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