Antidiabetic effects of Bisamide Derivative of Dicarboxylic Acid in metabolic disorders

Pakhomova, V. P., Nebolsin, V. E., Pershina, O. V., Krupin, V. A., Sandrikina, L. A., Pan, E. S., Ermakova, N. N., Vaizova, O. E., Widera, D. ORCID: https://orcid.org/0000-0003-1686-130X, Grimm, W.-D., Kravtsov, V. Y.’e., Afanasiev, S. A., Morozov, S. G., Kubatiev, A. A., Dygai, A. M. and Skurikhin, E. G. (2020) Antidiabetic effects of Bisamide Derivative of Dicarboxylic Acid in metabolic disorders. International Journal of Molecular Sciences, 21 (3). 991. ISSN 1422-0067 doi: 10.3390/ijms21030991

Abstract/Summary

In clinical practice, metabolic syndrome can lead to multiple complications, including diabetes. It remains unclear, which component of the metabolic syndrome (obesity, inflammation, hyperglycemia or insulin resistance) has the strongest inhibitory effect on stem cells involved in beta cell regeneration. This makes it challenging to develop effective treatment options for complications such as diabetes. In our study, experiments were performed on male C57BL/6 mice where metabolic disorders have been introduced experimentally by a combination of streptozotocin-treatment and high-fat diet. We evaluated the biological effects of Bisamide Derivative of Dicarboxylic Acid (BDDA) and its impact on pancreatic stem cells in vivo. To assess the impact of BDDA, we applied a combination of histological and biochemical methods along with a cytometric analysis of stem cell and progenitor cell markers. We show that in mice with metabolic disorders, BDDA has a positive effect on lipid and glucose metabolism. The pancreatic restoration was associated with a decrease of the inhibitory effects of inflammation and obesity factors on pancreatic stem cells. Our data show that BDDA increases the number of pancreatic stem cells. Thus, BDDA could be used as a new compound for treating complications of the metabolic syndrome such as diabetes.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/88851
Identification Number/DOI	10.3390/ijms21030991
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
Publisher	MDPI
Download/View statistics	View download statistics for this item