Biomimetic and electroactive 3D scaffolds for human neural crest-derived stem cell expansion and osteogenic differentiation

Iandolo, D., Sheard, J., Katarivas Levy, G., Pitsalidis, C., Tan, E., Dennis, A., Kim, J.-S., Markaki, A., Widera, D. ORCID: https://orcid.org/0000-0003-1686-130X and Owens, R. (2020) Biomimetic and electroactive 3D scaffolds for human neural crest-derived stem cell expansion and osteogenic differentiation. MRS Communications, 10 (1). pp. 179-187. ISSN 2159-6859 doi: 10.1557/mrc.2020.10

Abstract/Summary

Osteoporosis is a skeletal disease characterized by bone loss and bone microarchitectural deterioration. The combination of smart materials and stem cells represents a new therapeutic approach. In the present study, highly porous scaffolds are prepared by combining the conducting polymer PEDOT:PSS with collagen type I, the most abundant protein in bone. The inclusion of collagen proves to be an effective way to modulate their mechanical properties and it induces an increase in scaffolds’ electrochemical impedance. The biomimetic scaffolds support neural crest-derived stem cell osteogenic differentiation, with no need for scaffold pre-conditioning contrarily to other reports.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/88430
Identification Number/DOI	10.1557/mrc.2020.10
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
Publisher	Cambridge University Press
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