Yb(III), Sm(III) and La(III) complexes of a tetradentate pyridoxal Schiff base ligand: their DNA-binding activity and bio-imaging applications

Chakraborty, M., Mondal, S., Cardin, C. ORCID: https://orcid.org/0000-0002-2556-9995, Rheingold, A. L., Das Mukhopadhyay, C. and Kumar Chattopadhyay, S. (2019) Yb(III), Sm(III) and La(III) complexes of a tetradentate pyridoxal Schiff base ligand: their DNA-binding activity and bio-imaging applications. Polyhedron, 175. 114167. ISSN 0277-5387 doi: 10.1016/j.poly.2019.114167

Abstract/Summary

Yb(III), Sm(III) and La(III) complexes of a tetradentate Schiff base ligand, bis(pyridoxylidene)ethyelenediamine, are reported. Single crystal X-ray crystal structures of the complexes reveal that in all of them the Ln(III) ions are in a distorted dodecahedral geometry with N4O4-coordination environment provided by two coordinated ligands. Fluorescence spectroscopy shows that in the Yb(III) and Sm(III) complexes energy transfer from ligand centered excited state leads to population of emissive f-f excited states. The reported complexes bind to ct-DNA, with high binding constant (Kb) comparable to those which bind by intercalative mode. Cytotoxicity study shows that the complexes have quite low cytotoxicity towards HeLa cell. Further, they exhibited fast response, bright fluorescence and stability at physiological pH, making them suitable for use in fluorescence bio-imaging.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/86774
Identification Number/DOI	10.1016/j.poly.2019.114167
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Publisher	Elsevier
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