Metal complexes of flavonoids: their synthesis, characterization, and enhanced anti-oxidant and anti-cancer activities

Khater, M., Ravishankar, D., Greco, F. and Osborn, H. ORCID: https://orcid.org/0000-0002-0683-0457 (2019) Metal complexes of flavonoids: their synthesis, characterization, and enhanced anti-oxidant and anti-cancer activities. Future Medicinal Chemistry, 11 (21). ISSN 1756-8927 doi: 10.4155/fmc-2019-0237

Abstract/Summary

Flavonoids are polyphenolic compounds of natural origin. They are extensively studied within drug discovery programmes due to their wide ranging biological activities such as anti-microbial, anti-oxidant, anti-tumor, neuroprotective and cardioprotective properties. The ability of flavonoids to coordinate with metal atoms has provided new leads for drug discovery programmes, with better pharmacological activities and clinical profiles than the parent flavonoids. In this review, the enhanced anti-oxidant and anti-cancer activities of flavonoid metal complexes versus the parent flavonoids are discussed. Possible mechanisms of action for the metal complexes, such as DNA binding and apoptosis induction, are also presented alongside an overview of the synthesis of the metal complexes, and the different techniques used for their characterization.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/86372
Identification Number/DOI	10.4155/fmc-2019-0237
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Medicinal Chemistry Research Group Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Publisher	Future Science Group
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