Chitosan/poly(2-ethyl-2-oxazoline) films for ocular drug delivery: Formulation, miscibility, in vitro and in vivo studies

Abilova, G. K., Kaldybekov, D. B., Ozhmukhametova, E. K., Saimova, A. Z., Kazybayeva, D. S., Irmukhametova, G. S. and Khutoryanskiy, V. V. ORCID: https://orcid.org/0000-0002-7221-2630 (2019) Chitosan/poly(2-ethyl-2-oxazoline) films for ocular drug delivery: Formulation, miscibility, in vitro and in vivo studies. European Polymer Journal, 116. pp. 311-320. ISSN 0014-3057 doi: 10.1016/j.eurpolymj.2019.04.016

Abstract/Summary

Polymeric films were prepared based on chitosan and its blends with poly(2-ethyl-2-oxazoline) by casting from aqueous solutions. These materials were characterised using a number of physicochemical techniques, including Fourier-transform infrared spectroscopy, thermal gravimetric analysis, differential scanning calorimetry, wide angle x-ray diffraction, tensile testing and scanning electron microscopy. All these studies indicate that there is a weak intermacromolecular hydrogen bonding between these polymers, which facilitates their complete miscibility in solid state. These films were formulated with sodium fluorescein as a model drug and were evaluated for their potential application in ocular drug delivery both in vitro and in vivo. It was established that the films are biocompatible and mucoadhesive; they are capable of providing a sustained drug release when administered topically on the cornea.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/83324
Identification Number/DOI	10.1016/j.eurpolymj.2019.04.016
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Thermal Analysis (CAF) Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Xray (CAF) Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Electron Microscopy Laboratory (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Publisher	Elsevier
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