Discovery of novel 1,2,4-triazolo-1,2,4-triazines with thiomethylpyridine hinge binders as potent c-Met kinase inhibitors

Dadashpour, S., Kucukkilinc, T. T., Ayazgok, B., Hosseinimehr, S. J., Chippindale, A. ORCID: https://orcid.org/0000-0002-5918-8701, Foroumadi, A. and Irannejad, H. (2019) Discovery of novel 1,2,4-triazolo-1,2,4-triazines with thiomethylpyridine hinge binders as potent c-Met kinase inhibitors. Future Medicinal Chemistry, 11 (10). pp. 1119-1136. ISSN 1756-8927 doi: 10.4155/fmc-2018-0412

Abstract/Summary

Mesenchymal-epithelial transition factor HGF/c-Met overactivation is involved in diverse human cancers. Herein, we report the synthesis and biological evaluation of thiomethylpyridine-linked triazolotriazines as c-Met kinase inhibitors.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/82834
Identification Number/DOI	10.4155/fmc-2018-0412
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
Publisher	Future Science Group
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