Anhedonia and depression severity dissociated by dmPFC resting-state functional connectivity in adolescents

Rzepa, E. and McCabe, C. ORCID: https://orcid.org/0000-0001-8704-3473 (2018) Anhedonia and depression severity dissociated by dmPFC resting-state functional connectivity in adolescents. Journal of Psychopharmacology, 32 (10). pp. 1067-1074. ISSN 1461-7285 doi: 10.1177/0269881118799935

Abstract/Summary

Introduction: Given the heterogeneity within depression, in this study we aim to examine how RSFC in adolescents is related to anhedonia and depression severity on a continuum in line with the RDoC approach. Methods: We examined how RSFC in the dorsal medial prefrontal cortex (dmPFC), nucleus accumbens (NAcc) and pregenual anterior cingulate cortex (pgACC) was related to anhedonia and depression severity in eighty six adolescents (13-21 yrs.). Results: We found both anhedonia and depression severity related to decreased dmPFC RSFC with the precuneus, a part of the default mode network. However we also found that increased dmPFC connectivity with the ACC/paracingulate gyrus related to anhedonia whereas increased RSFC with the frontal pole related to depression severity. Discussion: This work extends the view that the dmPFC is a potential therapeutic target for depression in two ways. 1. We report dmPFC connectivity in adolescents and 2. We show different dmPFC RSFC specific to anhedonia and depression severity, providing neural targets for intervention in young people at risk of depression.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/78739
Item Type	Article
Refereed	Yes
Divisions	Interdisciplinary Research Centres (IDRCs) > Centre for Integrative Neuroscience and Neurodynamics (CINN) Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology Life Sciences > School of Psychology and Clinical Language Sciences > Neuroscience Life Sciences > School of Psychology and Clinical Language Sciences > Psychopathology and Affective Neuroscience
Publisher	Sage Publications
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