Supramolecular threading of peptide hydrogel fibrils

Hauptstein, N., De Leon-Rodriguez, L. M., Mitra, A. K., Hemar, Y., Kavianinia, I., Li, N., Castelletto, V., Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926 and Brimble, M. A. (2018) Supramolecular threading of peptide hydrogel fibrils. ACS Biomaterials Science & Engineering, 4 (8). pp. 2733-2738. ISSN 2373-9878 doi: 10.1021/acsbiomaterials.8b00283

Abstract/Summary

There is an increasing demand for biocompatible materials in biomedical applications. Herein, we report a modified α-helical decapeptide segment from the cardiac troponin C, which self-assembles into fibers with a secondary β-sheet structure. These fibers cross-link via a novel supramolecular threading mechanism which results in an atypical stiff hydrogel (G′ ≈ 13 kPa). In this work, we provide a first insight into the understanding of such remarkable cross-linking mechanism, which will aid in the development of new biomaterials with unique properties.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/78115
Identification Number/DOI	10.1021/acsbiomaterials.8b00283
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Publisher	American Chemical Society
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