Granulosa cell apoptosis in the ovarian follicle - a changing view

Regan, S. L. P., Knight, P. G. ORCID: https://orcid.org/0000-0003-0300-1554, Yovich, J. L., Leung, Y., Arfuso, F. and Dharmarajan, A. (2018) Granulosa cell apoptosis in the ovarian follicle - a changing view. Frontiers in Endocrinology, 9. 61. ISSN 1664-2392 doi: 10.3389/fendo.2018.00061

Abstract/Summary

Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal development and has limited predictive capability regarding oocyte quality or the ensuing pregnancy rate infertilization programs. This review article covers our revised understanding of the process of apoptosis within the ovarian follicle, its three phenotypes, the major signaling pathways underlying apoptosis as well as the associated mitochondrial pathways.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/76236
Identification Number/DOI	10.3389/fendo.2018.00061
Refereed	Yes
Divisions	Life Sciences > School of Biological Sciences > Biomedical Sciences
Publisher	Frontiers
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