The use of mesenchymal stromal cells in treatment of lung disorders

Kardia, E., Zakaria, N., Halim, N. S. S. A., Widera, D. ORCID: https://orcid.org/0000-0003-1686-130X and Yahaya, B. H. (2017) The use of mesenchymal stromal cells in treatment of lung disorders. Regenerative Medicine, 12 (2). pp. 2013-2016. ISSN 1746-076X doi: 10.2217/rme-2016-0112

Abstract/Summary

The therapeutic use of mesenchymal stromal cells (MSCs) represents a promising alternative clinical strategy for treating acute and chronic lung disorders. Several pre-clinical reports demonstrated that MSCs can secrete multiple paracrine factors and that their immunomodulatory properties can support endothelial and epithelial regeneration, modulate the inflammatory cascade, and protect lungs from damage. The effects of MSC transplantation into patients suffering from lung diseases should be fully evaluated through careful assessment of safety and associated risks, which is a prerequisite for translation of pre-clinical research into clinical practise. In this article we summarise the current status of pre-clinical research and review initial MSC-based clinical trials for treating lung injuries and lung disorders.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/68628
Identification Number/DOI	10.2217/rme-2016-0112
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
Publisher	Future Medicine
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