The LRRK2-macroautophagy axis and its relevance to Parkinson's Disease

Manzoni, C. (2017) The LRRK2-macroautophagy axis and its relevance to Parkinson's Disease. Biochemical Society Transactions, 45 (1). pp. 155-162. ISSN 1470-8752 doi: 10.1042/bst20160265

Abstract/Summary

A wide variety of different functions and an impressive array of interactors have been associated with leucine-rich repeat kinase 2 (LRRK2) over the years. Here, I discuss the hypothesis that LRRK2 may be capable of interacting with different proteins at different times and places, therefore, controlling a plethora of diverse functions based on the different complexes formed. Among these, I will then focus on macroautophagy in the general context of the endolysosomal system. First, the relevance of autophagy in Parkinson's disease will be evaluated giving a brief overview of all the relevant Parkinson's disease genes; then, the association of LRRK2 with macroautophagy and the endolysosomal pathway will be analyzed based on the supporting literature.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/68610
Identification Number/DOI	10.1042/bst20160265
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
Publisher	Portland Press
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