Arterial spin labelling shows functional depression of non-lesion tissue in chronic Wernicke’s aphasia

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Robson, H., Specht, K., Beaumont, H., Parkes, L. M., Sage, K., Lambon Ralph, M. A. and Zahn, R. (2017) Arterial spin labelling shows functional depression of non-lesion tissue in chronic Wernicke’s aphasia. Cortex, 92. pp. 249-260. ISSN 0010-9452 doi: 10.1016/j.cortex.2016.11.002

Abstract/Summary

Behavioural impairment post-stroke is a consequence of structural damage and altered functional network dynamics. Hypoperfusion of intact neural tissue is frequently observed in acute stroke, indicating reduced functional capacity of regions outside the lesion. However, cerebral blood flow is rarely investigated in chronic stroke. This study investigated cerebral blood flow in individuals with chronic Wernicke’s aphasia and examined the relationship between lesion, cerebral blood flow and neuropsychological impairment. Arterial spin labelling cerebral blood flow imaging and structural MRIs were collected in 12 individuals with chronic Wernicke’s aphasia and 13 age-matched control participants. Joint independent component analysis (jICA) investigated the relationship between structural lesion and hypoperfusion. Partial correlations explored the relationship between lesion, hypoperfusion and language measures. Joint ICA revealed significant differences between the control and WA groups reflecting a large area of structural lesion in the left posterior hemisphere and an associated area of hypoperfusion extending into grey matter surrounding the lesion. Small regions of remote cortical hypoperfusion were observed, ipsilateral and contralateral to the lesion. Significant correlations were observed between the neuropsychological measures (naming, repetition, reading and semantic association) and the jICA component of interest in the WA group. Additional ROI analyses found a relationship between perfusion surrounding the core lesion and the same neuropsychological measures.

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Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/67955
Item Type	Article
Refereed	Yes
Divisions	Interdisciplinary Research Centres (IDRCs) > Centre for Integrative Neuroscience and Neurodynamics (CINN) Life Sciences > School of Psychology and Clinical Language Sciences > Department of Clinical Language Sciences
Uncontrolled Keywords	Stroke, Aphasia, Wernicke's Aphasia, Auditory comprehension, Joint Independent Component Analysis, Arterial Spin Labeling, Diaschisis, Hyoperfusion
Publisher	Elsevier
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Funders:	Stroke Association	The sponsoring bodies who contributed funding for the creation of this item. Example: NERC Example: The Royal Society of Chemistry A pick list of funders may appear as you type in the funder's name in full or as an acronym. Select a correct match to complete the field or type in a new entry in full. For new entries, the full name is preferred.
Projects:	Profiling chronic and recovered language comprehension networks post stroke: Psychoacoustic, neuropsychological and fMRI invesitigations Funded by: Stroke Association (TSA SRTF 2012/02 - £170,477) Local Lead (PI): Holly Robson 14 September 2012 - 13 September 2015	Click Add to select your project (received at Reading) from an autocomplete list.

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Date Deposited:	27 Nov 2019 11:39	Date item deposited into CentAUR
Last Modified:	09 Jun 2024 09:16	Date item last modified

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