Structure-activity relationship of condensed tannins and synergism with trans-cinnamaldehyde against Caenorhabditis elegans

Ropiak, H. M., Desrues, O., Williams, A. R., Ramsay, A., Mueller-Harvey, I. and Thamsborg, S. M. (2016) Structure-activity relationship of condensed tannins and synergism with trans-cinnamaldehyde against Caenorhabditis elegans. Journal of Agricultural and Food Chemistry, 64 (46). pp. 8795-8805. ISSN 1520-5118 doi: 10.1021/acs.jafc.6b03842

Abstract/Summary

Parasitic gastrointestinal nematodes (GIN) of livestock are increasingly developing resistance to synthetic nematocidal drugs. Moreover, the use of nematocides can induce ecotoxicity by affecting free-living nematodes. Condensed tannins (CT) are a structurally diverse group of bioactive plant compounds possessing anthelmintic activity against GIN. We investigated the relationship between the chemical structure of contrasting, purified CT and nematocidal effects using Caenorhabditis elegans. We also explored whether the nematocidal activity of CT could synergize with trans-cinnamaldehyde (CIN). A non-significant correlation was evident between the ability of CT fractions to inhibit C. elegans motility and the molar proportion of prodelphinidin subunits in purified CT samples. Synergistic inhibition of motility was achieved by combinations of CT and CIN. Galloylation of procyanidins was also a key factor for synergy. To increase the nematocidal effect of CT, plant sources containing CT with specific structural features could be selected and combined with compounds acting in synergy.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/67938
Identification Number/DOI	10.1021/acs.jafc.6b03842
Refereed	Yes
Divisions	Interdisciplinary Research Centres (IDRCs) > Walker Institute Interdisciplinary centres and themes > Centre for Food Security Life Sciences > School of Agriculture, Policy and Development > Department of Animal Sciences > Animal, Dairy and Food Chain Sciences (ADFCS)- DO NOT USE
Publisher	American Chemical Society
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