Platelets stop us leaking

Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2016) Platelets stop us leaking. Blood, 127 (12). pp. 1528-1529. ISSN 0006-4971 doi: 10.1182/blood-2016-01-692186

Abstract/Summary

In this issue of Blood, Welsh and colleagues determine how platelet thrombi limit the loss of plasma-borne proteins from the microvasculature. 1 The concept that platelets prevent leakage from blood vessels following a penetrating injury will come as little surprise to most readers, but exactly how platelets physically contribute to this process is not well understood. Such injuries result in the loss of blood cells and plasma into the surrounding tissues, and both forms of loss must be halted quickly. Platelets are believed to form the first line of defense in such situations, forming a thrombus that is capable of plugging the hole and supplying molecules that contribute to localized inflammation and wound healing.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/67337
Identification Number/DOI	10.1182/blood-2016-01-692186
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR) Life Sciences > School of Biological Sciences > Biomedical Sciences
Uncontrolled Keywords	platelets, thrombosis, haemostasis, thrombi
Publisher	American Society of Hematology
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