Maleimide-bearing nanogels as novel mucoadhesive materials for drug delivery

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Tonglairoum, P., Brannigan, R. P., Opanasopit, P. and Khutoryanskiy, V. V. ORCID: https://orcid.org/0000-0002-7221-2630 (2016) Maleimide-bearing nanogels as novel mucoadhesive materials for drug delivery. Journal of Materials Chemistry B, 4 (40). pp. 6581-6587. ISSN 0959-9428 doi: 10.1039/C6TB02124G

Abstract/Summary

Novel maleimide-functionalised nanogels have been synthesised via the polymerisation of 2,5-dimethylfuran-protected 3-maleimidoethyl butylacrylate in the presence of presynthesised poly(N-vinylpyrrolidone) (PVP) nanogel scaffolds using surfactant-free emulsion polymerisation techniques. The protected maleimide nanogels were subsequently deprotected to generate the reactive maleimide group via a retro-Diels-Alder reaction. These activated nanogels were found to exhibit excellent mucoadhesive properties on ex vivo conjunctival tissue when compared to the known mucoadhesive chitosan. In order to determine the viability of the materials as drug carriers, nanogels were loaded with a model drug compound and the in vitro release kinetics were analysed. The nanogels could sustain the release of a model drug compound over several hours owing to the swellable hydrophilic nanogel structure, exhibiting first order release kinetics. As a consequence, these findings support the potential of these maleimide-bearing nanogels as a novel platform for sustained ocular drug delivery.

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Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/67056
Item Type	Article
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > NMR (CAF) Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Thermal Analysis (CAF) Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Electron Microscopy Laboratory (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Publisher	Royal Society of Chemistry
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Funders:	Leverhulme Trust	The sponsoring bodies who contributed funding for the creation of this item. Example: NERC Example: The Royal Society of Chemistry A pick list of funders may appear as you type in the funder's name in full or as an acronym. Select a correct match to complete the field or type in a new entry in full. For new entries, the full name is preferred.
Projects:	Developing in vitro approaches for testing mucoadhesive drug delivery systems Funded by: Leverhulme Trust (RPG-2013-017 - £160,851) Local Lead (PI): Vitaliy Khutoryanskiy 1 August 2013 - 31 July 2016	Click Add to select your project (received at Reading) from an autocomplete list.

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Date Deposited:	05 Oct 2016 08:26	Date item deposited into CentAUR
Last Modified:	09 Jun 2024 04:14	Date item last modified

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