Impact of high fat diets, prebiotics and probiotics on gut microbiota and immune function, with relevance to elderly populations

Liu, Y., Gibson, G. R. ORCID: https://orcid.org/0000-0002-0566-0476 and Walton, G. E. ORCID: https://orcid.org/0000-0001-5426-5635 (2016) Impact of high fat diets, prebiotics and probiotics on gut microbiota and immune function, with relevance to elderly populations. Nutrition and Aging, 3 (2-4). pp. 171-192. ISSN 1879-7725 doi: 10.3233/NUA-150058

Abstract/Summary

According to WHO, the number of people over 60 years of age is set to rise to 2 billion by 2050. Dysbiosis of microbial composition and impaired immune function have been observed in elderly persons compared to younger adults. As a result, the aging population has a higher disease risk than other age groups. In addition, high fat intakes have been observed to exert negative effects on microbial composition and immune function in murine studies. Elderly people have higher fat intakes than recommended levels, and this may make them more vulnerable to disease risk. Therefore, the impact of high fat consumption on elderly populations may be of relevance. Prebiotics and probiotics have been shown to have positive effects on microbiota composition and immune function in the elderly. This review describes aged-related changes in gut microbiome of elderly persons. It will also summarise studies concerning the impact of prebiotics, probiotics and high fat diets on microbiota composition and immune function.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/65835
Identification Number/DOI	10.3233/NUA-150058
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Food Microbial Sciences Research Group
Publisher	IOS Press
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