Membrane-initiated actions of estrogens in neuroendocrinology: emerging principles

Vasudevan, N. ORCID: https://orcid.org/0000-0003-4326-3938 and Pfaff, D. W. (2007) Membrane-initiated actions of estrogens in neuroendocrinology: emerging principles. Endocr Rev, 28 (1). pp. 1-19. ISSN 0163-769X (Print)

Abstract/Summary

Hormonal ligands for the nuclear receptor superfamily have at least two interacting mechanisms of action: 1) classical transcriptional regulation of target genes (genomic mechanisms); and 2) nongenomic actions that are initiated at the cell membrane, which could impact transcription. Although transcriptional mechanisms are increasingly well understood, membrane-initiated actions of these ligands are incompletely understood. Historically, this has led to a considerable divergence of thought in the molecular endocrine field. We have attempted to uncover principles of hormone action that are relevant to membrane-initiated actions of estrogens. There is evidence that the membrane-limited actions of hormones, particularly estrogens, involve the rapid activation of kinases and the release of calcium. Membrane actions of estrogens, which activate these rapid signaling cascades, can also potentiate nuclear transcription. These signaling cascades may occur in parallel or in series but subsequently converge at the level of modification of transcriptionally relevant molecules such as nuclear receptors and/or coactivators. In addition, other hormones or neurotransmitters may also activate cascades to crosstalk with estrogen receptor-mediated transcription. The idea of synergistic coupling between membrane-initiated and genomic actions of hormones fundamentally revises the paradigms of cell signaling in neuroendocrinology.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/58931
Refereed	Yes
Divisions	No Reading authors. Back catalogue items
Uncontrolled Keywords	Animals Biological Transport Cell Membrane/*physiology Estrogens/*physiology Humans Models, Biological *Nervous System Physiology *Neuroendocrinology Protein Binding Protein Processing, Post-Translational Receptors, Estrogen/physiology Signal Transduction/*physiology Transcription, Genetic
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