Dysregulation of granulosal bone morphogenetic protein receptor 1B density is associated with reduced ovarian reserve and the age-related decline in human fertility

Regan, S. L. P., Knight, P. G. ORCID: https://orcid.org/0000-0003-0300-1554, Yovich, J. L., Stanger, J. D., Leung, Y., Arfuso, F., Dharmarajan, A. and Almahbobi, G. (2016) Dysregulation of granulosal bone morphogenetic protein receptor 1B density is associated with reduced ovarian reserve and the age-related decline in human fertility. Molecular and Cellular Endocrinology, 425. pp. 84-93. ISSN 1872-8057 doi: 10.1016/j.mce.2016.01.016

Abstract/Summary

Reproductive ageing is linked to the depletion of ovarian primordial follicles, which causes an irreversible change to ovarian cellular function and the capacity to reproduce. The current study aimed to profile the expression of bone morphogenetic protein receptor, (BMPR1B) in 53 IVF patients exhibiting different degrees of primordial follicle depletion. The granulosa cell receptor density was measured in 403 follicles via flow cytometry. A decline in BMPR1B density occurred at the time of dominant follicle selection and during the terminal stage of folliculogenesis in the 23-30 y good ovarian reserve patients. The 40+ y poor ovarian reserve patients experienced a reversal of this pattern. The results demonstrate an association between age-induced depletion of the ovarian reserve and BMPR1B receptor density at the two critical time points of dominant follicle selection and pre-ovulatory follicle maturation. Dysregulation of BMP receptor signalling may inhibit the normal steroidogenic differentiation required for maturation in older patients.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/55683
Identification Number/DOI	10.1016/j.mce.2016.01.016
Refereed	Yes
Divisions	Life Sciences > School of Biological Sciences > Biomedical Sciences
Publisher	Elsevier
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