From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition

Young, A. M. H., Chakrabarti, B. ORCID: https://orcid.org/0000-0002-6649-7895, Roberts, D., Lai, M.-C., Suckling, J. and Baron-Cohen, S. (2016) From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition. Molecular Autism, 7 (1). 9. ISSN 2040-2392 doi: 10.1186/s13229-016-0068-x

Abstract/Summary

Growing evidence points toward a critical role for early (prenatal) atypical neurodevelopmental processes in the aetiology of autism spectrum condition (ASC). One such process that could impact early neural development is inflammation. We review the evidence for atypical expression of molecular markers in the amniotic fluid, serum, cerebrospinal fluid (CSF), and the brain parenchyma that suggest a role for inflammation in the emergence of ASC. This is complemented with a number of neuroimaging and neuropathological studies describing microglial activation. Implications for treatment are discussed.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/52480
Identification Number/DOI	10.1186/s13229-016-0068-x
Refereed	Yes
Divisions	Interdisciplinary Research Centres (IDRCs) > Centre for Integrative Neuroscience and Neurodynamics (CINN) Interdisciplinary centres and themes > ASD (Autism Spectrum Disorders) Research Network Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology Life Sciences > School of Psychology and Clinical Language Sciences > Neuroscience Interdisciplinary Research Centres (IDRCs) > Centre for Cognition Research (CCR) Life Sciences > School of Psychology and Clinical Language Sciences > Psychopathology and Affective Neuroscience
Publisher	BioMed Central
Download/View statistics	View download statistics for this item