Ras: the stress and the strain

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. (2006) Ras: the stress and the strain. Journal of Molecular and Cellular Cardiology, 41 (4). pp. 595-600. ISSN 0022-2828 doi: 10.1016/j.yjmcc.2006.06.075

Abstract/Summary

The last 10–15 years have seen an expansion in the understanding of the intracellular signalling pathways activated in cardiac myocytes in response to hypertrophic or lethal stimuli. The mitogen-activated protein kinases (MAPKs) were identified as potential key mediators of cardiac myocyte responses in the early to mid-1990's, with the extracellular signal-regulated kinases 1/2 (ERK1/2) being potently activated by heterotrimeric Gq protein-coupled receptor (GqPCR) agonists, and the c-Jun N-terminal kinases (JNKs) and p38-MAPKs being potently activated by cell stresses.