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Ura, S., Pollitt, A. Y. 
ORCID: https://orcid.org/0000-0001-8706-5154, Veltman, D. M., Morrice, N. A., Machesky, L. M. and Insall, R. H.
(2012)
Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation.
Current Biology, 22 (7).
pp. 553-561.
ISSN 0960-9822
doi: 10.1016/j.cub.2012.02.020
Abstract/Summary
Regulated dephosphorylation of a fraction of the cellular SCAR pool is a key step in SCAR activation during pseudopod growth. Phosphorylation increases autoinhibition of the intact complex. Dephosphorylation weakens this interaction and facilitates SCAR activation but also destabilizes the protein. We show that SCAR is specifically dephosphorylated in pseudopods, increasing activation by Rac and lipids and supporting positive feedback of pseudopod growth.
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| Item Type | Article |
| URI | https://reading-clone.eprints-hosting.org/id/eprint/44793 |
| Item Type | Article |
| Refereed | Yes |
| Divisions | Life Sciences > School of Biological Sciences > Biomedical Sciences |
| Publisher | Elsevier |
| Download/View statistics | View download statistics for this item |
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