Synthesis and evaluation of novel boron-containing complexes of potential use for the selective treatment of malignant melanoma

Bonjoch, J., Drew, M. G.B., Gonzalez, A., Greco, F., Jawaid, S., Osborn, H. M. I. ORCID: https://orcid.org/0000-0002-0683-0457, Williams, N. A.O. and Yaqoob, P. ORCID: https://orcid.org/0000-0002-6716-7599 (2008) Synthesis and evaluation of novel boron-containing complexes of potential use for the selective treatment of malignant melanoma. Journal of Medicinal Chemistry, 51 (20). pp. 6604-6608. ISSN 0022-2623 doi: 10.1021/jm8007745

Abstract/Summary

Boron-containing complexes that have the potential to irreversibly accumulate in melanoma cells have been prepared by reaction of amino acids with 9-methoxy-9-borabicyclo[3.3.1]nonane. The ability of each complex to act as a substrate for tyrosinase has been probed by oximetry. Increased uptake of the lead candidate in a tyrosinase-rich cell line, compared with a tyrosinase-absent cell line, is reported, with results correlating well with that for a drug currently approved for BNCT.