Norepinephrine ignites local hot spots of neuronal excitation: how arousal amplifies selectivity in perception and memory

Mather, M., Clewett, D., Sakaki, M. ORCID: https://orcid.org/0000-0003-1993-5765 and Hearley, C. W. (2016) Norepinephrine ignites local hot spots of neuronal excitation: how arousal amplifies selectivity in perception and memory. Behavioral and Brain Sciences, 39. e200. ISSN 0140-525X doi: 10.1017/S0140525X15000667

Abstract/Summary

Arousal sometimes enhances and sometimes impairs perception and memory. In our Glutamate Amplifies Noradrenergic Effects (GANE) model, glutamate at active synapses interacts with norepinephrine released by the locus coeruleus to create local ‘hot spots’ of activity that enable the selective effects of arousal. This hot spot mechanism allows local cortical regions to self-regulate norepinephrine release based on current activation levels. In turn, hot spots bias global energetic delivery and functional network connectivity to enhance processing of high priority representations and impair processing of lower priority representations.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/40516
Identification Number/DOI	10.1017/S0140525X15000667
Refereed	Yes
Divisions	Interdisciplinary Research Centres (IDRCs) > Centre for Integrative Neuroscience and Neurodynamics (CINN) Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology Life Sciences > School of Psychology and Clinical Language Sciences > Psychopathology and Affective Neuroscience
Publisher	Cambridge University Press
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