New insights on the role of paired membrane structures in coronavirus replication

V'kovski, P., Al-Mulla, H., Thiel, V. and Neuman, B. W. (2015) New insights on the role of paired membrane structures in coronavirus replication. Virus Research, 202. pp. 33-40. ISSN 0168-1702 doi: 10.1016/j.virusres.2014.12.021

Abstract/Summary

The replication of coronaviruses, as in other positive-strand RNA viruses, is closely tied to the formation of membrane-bound replicative organelles inside infected cells. The proteins responsible for rearranging cellular membranes to form the organelles are conserved not just among the Coronaviridae family members, but across the order Nidovirales. Taken together, these observations suggest that the coronavirus replicative organelle plays an important role in viral replication, perhaps facilitating the production or protection of viral RNA. However, the exact nature of this role, and the specific contexts under which it is important have not been fully elucidated. Here, we collect and interpret the recent experimental evidence about the role and importance of membrane-bound organelles in coronavirus replication.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/40455
Identification Number/DOI	10.1016/j.virusres.2014.12.021
Refereed	Yes
Divisions	Life Sciences > School of Biological Sciences > Biomedical Sciences Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Electron Microscopy Laboratory (CAF)
Publisher	Elsevier
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