nor-Mevaldic acid surrogates as selective antifungal agent leads against Botrytis cinerea. Enantioselective preparation of 4-hydroxy-6-(1-phenylethoxy)tetrahydro-2H-pyran-2-one

Botubol-Ares, J. M., Durán-Peña, M. J., Hernández-Galán, R., Collado, I. G., Harwood, L. M. ORCID: https://orcid.org/0000-0002-8442-7380 and Macías-Sánchez, A. (2015) nor-Mevaldic acid surrogates as selective antifungal agent leads against Botrytis cinerea. Enantioselective preparation of 4-hydroxy-6-(1-phenylethoxy)tetrahydro-2H-pyran-2-one. Bioorganic & Medicinal Chemistry, 23 (13). pp. 3379-3387. ISSN 0968-0896 doi: 10.1016/j.bmc.2015.04.048

Abstract/Summary

Solvent-free desymmetrisation of meso-dialdehyde 1 with chiral 1-phenylethan-1-ol, led to preparation of 4-silyloxy-6-alkyloxytetrahydro-2H-pyran-2-one (+)-3a with a 96:4 d.r. Deprotected lactone (+)-19a and the related racemic lactones 16a-18a present a lactone moiety resembling the natural substrate of HMG-CoA reductase and their antifungal properties have been evaluated against the phytopathogenic fungi Botrytis cinerea and Colletotrichum gloeosporioides. These compounds were selectively active against B. cinerea, while inactive against C. gloeosporioides.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/40343
Item Type	Article
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Uncontrolled Keywords	Antifungal agents; Desymmetrisation; Lactones; nor-Methyl mevaldate; Statins
Publisher	Elsevier
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