Signaling via NF-kappaB in the nervous system

Kaltschmidt, B., Widera, D. ORCID: https://orcid.org/0000-0003-1686-130X and Kaltschmidt, C. (2005) Signaling via NF-kappaB in the nervous system. Biochimica Et Biophysica Acta-Molecular Cell Research, 1745 (3). pp. 287-99. ISSN 0167-4889 doi: 10.1016/j.bbamcr.2005.05.009

Abstract/Summary

Nuclear factor kappa B (NF-kappaB) is an inducible transcription factor present in neurons and glia. Recent genetic models identified a role for NF-kappaB in neuroprotection against various neurotoxins. Furthermore, genetic evidence for a role in learning and memory is now emerging. This review highlights our current understanding of neuronal NF-kappaB in response to synaptic transmission and summarizes potential physiological functions of NF-kappaB in the nervous system. This article contains a listing of NF-kappaB activators and inhibitors in the nervous system, furthermore specific target genes are discussed. Synaptic NF-kappaB activated by glutamate and Ca2+ will be presented in the context of retrograde signaling. A controversial role of NF-kappaB in neurodegenerative diseases will be discussed. A model is proposed explaining this paradox as deregulated physiological NF-kappaB activity, where novel results are integrated, showing that p65 could be turned from an activator to a repressor of anti-apoptotic genes.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/39489
Identification Number/DOI	10.1016/j.bbamcr.2005.05.009
Refereed	Yes
Divisions	No Reading authors. Back catalogue items Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
Publisher	Elsevier
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