A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor

Baxendale, I.R., Ley, S.V., Smith, C. ORCID: https://orcid.org/0000-0002-5911-5836, Tamborini, L. and Voica, A.F. (2008) A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor. Journal of Combinatorial Chemistry, 10 (6). pp. 851-857. ISSN 1520-4774 doi: 10.1021/cc800070a

Abstract/Summary

A scalable method for the preparation of 4,5-disubstituted thiazoles and imidazoles as distinct regioisomeric products using a modular flow microreactor has been devised. The process makes use of microfluidic reaction chips and packed immobilized-reagent columns to effect bifurcation of the reaction pathway.