Impairments in glucose tolerance can have a negative impact on cognitive function: a systematic research review

Lamport, D. J. ORCID: https://orcid.org/0000-0002-4592-0439, Lawton, C. L., Mansfield, M. W. and Dye, L. (2009) Impairments in glucose tolerance can have a negative impact on cognitive function: a systematic research review. Neuroscience and Biobehavioral Reviews, 33 (3). pp. 394-413. ISSN 0149-7634 doi: 10.1016/j.neubiorev.2008.10.008

Abstract/Summary

There is an increasing body of research investigating whether abnormal glucose tolerance is associated with cognitive impairments, the evidence from which is equivocal. A systematic search of the literature identified twenty-three studies which assessed either clinically defined impaired glucose tolerance (IGT) or variance in glucose tolerance within the clinically defined normal range (NGT). The findings suggest that poor glucose tolerance is associated with cognitive impairments, with decrements in verbal memory being most prevalent. However, the evidence for decrements in other domains was weak. The NGT studies report a stronger glucose tolerance-cognition association than the IGT studies, which is likely to be due to the greater number of glucose tolerance parameters and the more sensitive cognitive tests in the NGT studies compared to the IGT studies. It is also speculated that the negative cognitive impact of abnormalities in glucose tolerance increases with age, and that glucose consumption is most beneficial to individuals with poor glucose tolerance compared to individuals with normal glucose tolerance. The role of potential mechanisms are discussed.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/37035
Identification Number/DOI	10.1016/j.neubiorev.2008.10.008
Refereed	Yes
Divisions	No Reading authors. Back catalogue items
Uncontrolled Keywords	Impaired glucose tolerance; Glucose tolerance; Glucoregulation; Impaired glucoregulation; Cognitive performance; Cognition; Cognitive function; Cognitive tests; Memory; Attention; Psychomotor; Glucose
Publisher	Elsevier
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