Influence of SNPs in nutrient-sensitive candidate genes and gene–diet interactions on blood lipids: the DiOGenes study

Brahe, L. K., Ängquist, L., Larsen, L. H., Vimaleswaran, K. S. ORCID: https://orcid.org/0000-0002-8485-8930, Hager, J., Viguerie, N., Loos, R. J. F., Handjieva-Darlenska, T., Jebb, S. A., Hlavaty, P., Larsen, T. M., Martinez, J. A., Papadaki, A., Pfeiffer, A. F. H., van Baak, M. A., Sørensen, T. I. A., Holst, C., Langin, D., Astrup, A. and Saris, W. H. M. (2013) Influence of SNPs in nutrient-sensitive candidate genes and gene–diet interactions on blood lipids: the DiOGenes study. British Journal of Nutrition, 110 (05). pp. 790-796. ISSN 0007-1145 doi: 10.1017/S0007114512006058

Abstract/Summary

Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene–diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP–diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP–dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of − 0·26 mmol/l per A-allele/protein unit (95 % CI − 0·38, − 0·14, P= 0·000043). In conclusion, we investigated SNP–diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/34642
Item Type	Article
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
Uncontrolled Keywords	Blood lipids; Gene–diet interactions; Protein; Glycaemic index; SNPs
Publisher	Cambridge University Press
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