Spectroscopic signatures of an Fmoc–tetrapeptide, Fmoc and fluorene

Zou, Y., Razmkhah, K., Chmel, N. P., Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926 and Rodger, A. (2013) Spectroscopic signatures of an Fmoc–tetrapeptide, Fmoc and fluorene. RSC Advances, 3 (27). pp. 10854-10858. ISSN 2046-2069 doi: 10.1039/c3ra41979g

Abstract/Summary

The hydrophobic Fmoc [N-(fluorenyl)-9-methoxycarbonyl] unit is often conjugated to peptides to confer amphiphilicity on the molecules, and to introduce the potential for aromatic stacking interactions. In this paper we report spectroscopic data for fluorene, Fmoc and Fmoc conjugated to a small peptide (GRDS in this case) to enable interpretation of spectroscopic data collected on complex structures that can be created with Fmoc–peptide molecules. We report absorbance data (ultra violet and infrared), circular dichroism, linear dichroism (both film and Couette flow orientation) and Raman spectra. Orientations of the Fmoc chromophores in the linear dichroism studies are deduced.