Markers for nutrition studies: review of criteria for the evaluation of markers

de Vries, J., Antoine, J.-M., Burzykowski, T., Chiodini, A., Gibney, M., Kuhnle, G., Méheust, A., Pijls, L. and Rowland, I. (2013) Markers for nutrition studies: review of criteria for the evaluation of markers. European journal of nutrition, 52 (7). pp. 1685-1699. ISSN 1436-6215 doi: 10.1007/s00394-013-0553-3

Abstract/Summary

The following criteria were identified as essential elements in the evaluation of markers: (1) the marker has a causal biological link with the endpoint, (2) there is a significant association between marker and endpoint in the target population, (3) marker changes consistently with the endpoint, e.g., in response to an intervention, and (4) change in the marker explains a substantial proportion of the change in the endpoint in response to the intervention.