Dendritic cells interact with CD4 T cells in intestinal mucosa

Inman, C., Singha, S., Lewis, M., Bradley, B., Stokes, C. and Bailey, M. (2010) Dendritic cells interact with CD4 T cells in intestinal mucosa. Journal of Leukocyte Biology, 88 (3). pp. 571-578. ISSN 1938-3673 doi: 10.1189/jlb.0310161

Abstract/Summary

Absence of lymph nodes in nonmammalian species, expression of MHCII by APCs in the periphery, and the recent findings that T cells can change their polarization status after presentation in the lymph nodes imply a role for MHCII-mediated presentation outside the organized lymphoid tissue. This study shows that MHCII+ ECs and DCs from the intestinal mucosa of the pig can present antigen to T cells in vitro. In vivo, APCs colocalize with T cells in pig and mouse intestinal mucosa. In the pig, endothelium is involved in these interactions in neonates but not in adults, indicating different roles for stromal and professional APCs in the neonate compared with the adult. The ratio of expression of DQ and DR MHCII locus products was lower on ECs than on other mucosal APCs, indicating that the two types of cells present different peptide sets. Adult nonendothelial APCs expressed a higher ratio of DQ/DR than in neonates. These results suggest that mucosal DCs can present antigen locally to primed T cells and that stromal APCs are recruited to these interactions in some cases. This raises the possibility that local presentation may influence T cell responses at the effector stage after initial presentation in the lymph node.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/33296
Identification Number/DOI	10.1189/jlb.0310161
Refereed	Yes
Divisions	No Reading authors. Back catalogue items Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Food Microbial Sciences Research Group
Publisher	Society for Leukocyte Biology
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