SSRI administration reduces resting state functional connectivity in dorso-medial prefrontal cortex

McCabe, C. ORCID: https://orcid.org/0000-0001-8704-3473, Mishor, Z., Filippini, N., Cowen, P. J., Taylor, M. J. and Harmer, C. J. (2011) SSRI administration reduces resting state functional connectivity in dorso-medial prefrontal cortex. Molecular Psychiatry, 16 (6). pp. 592-594. ISSN 1476-5578 doi: 10.1038/mp.2010.138

Abstract/Summary

Recent evidence suggests that an area in the dorsal medial prefrontal cortex (dorsal nexus) shows dramatic increases in connectivity across a network of brain regions in depressed patients during the resting state;1 this increase in connectivity is suggested to represent hotwiring of areas involved in disparate cognitive and emotional functions.1, 2, 3 Sheline et al.1 concluded that antidepressant action may involve normalisation of the elevated resting state functional connectivity seen in depressed patients. However, the effects of conventional pharmacotherapy for depression on this resting state functional connectivity is not known and the effects of antidepressant treatment in depressed patients may be confounded by change in symptoms following treatment.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/33176
Identification Number/DOI	10.1038/mp.2010.138
Refereed	Yes
Divisions	No Reading authors. Back catalogue items Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology
Publisher	Nature Publishing Group
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