The collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts

Jones, R. R., Castelletto, V., Connon, C. J. and Hamley, I. W. (2013) The collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts. Molecular Pharmaceutics, 10 (3). pp. 1063-1069. ISSN 1543-8392 doi: 10.1021/mp300549d

Abstract/Summary

The collagen production of human dermal and corneal fibroblasts in contact with solutions of the peptide amphiphile (PA) C16–KTTKS is investigated and related to its self-assembly into nanotape structures. This PA is used in antiwrinkle cosmeceutical applications (trade name Matrixyl). We prove that C16–KTTKS stimulates collagen production in a concentration-dependent manner close to the critical aggregation concentration determined from pyrene fluorescence spectroscopy. This suggests that self-assembly and the stimulation of collagen production are inter-related.