Advanced search

Polymer therapeutics designed for a combination therapy of hormone-dependent cancer

Download
Full text not archived in this repository.
Advice

Please see our End User Agreement.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

Tools
Add to AnyAdd to TwitterAdd to FacebookAdd to LinkedinAdd to PinterestAdd to Email
Lists

Vicent, M. J., Greco, F., Nicholson, R. I., Paul, A., Griffiths , P. C. and Duncan, R. (2005) Polymer therapeutics designed for a combination therapy of hormone-dependent cancer. Angewandte Chemie-International Edition, 44 (26). pp. 4061-4066. ISSN 1521-3773 doi: 10.1002/anie.200462960

Abstract/Summary

Designer drug: A polymer therapeutic was designed for a combination therapy of breast cancer. N-(2-Hydroxypropyl)methacrylamide was used as the model polymer platform to prepare a unimolecular polymer conjugate (see picture, radius of gyration: 12.8 nm) that combines an endocrine (the aromatase inhibitor aminoglutethimide, blue) and a chemotherapeutic agent (the anthraxcycline antibiotic doxorubicin, red).

Altmetric Badge

Item Type Article
URI https://reading-clone.eprints-hosting.org/id/eprint/31496
Identification Number/DOI 10.1002/anie.200462960
Refereed Yes
Divisions No Reading authors. Back catalogue items
Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Uncontrolled Keywords Keywords: antitumor agents;drug delivery;drug design;polymers;tumor targeting
Publisher Wiley-Blackwell
Download/View statistics View download statistics for this item
Deposit Details

University Staff: Request a correction | Centaur Editors: Update this record

Search Google Scholar