Heme-induced biomarkers associated with red meat promotion of colon cancer are not modulated by the intake of nitrite

Chenni, F. Z., Tache, S., Naud, N., Hobbs, D. A., Kuhnle, G. G. C. ORCID: https://orcid.org/0000-0002-8081-8931, Pierre, F. H. and Corpet, D. E. (2013) Heme-induced biomarkers associated with red meat promotion of colon cancer are not modulated by the intake of nitrite. Nutrition and Cancer, 65 (2). pp. 227-233. ISSN 1532-7914 doi: 10.1080/01635581.2013.749291

Abstract/Summary

Red and processed meat consumption is associated with the risk of colorectal cancer. Three hypotheses are proposed to explain this association, via heme-induced oxidation of fat, heterocyclic amines, or N-nitroso compounds. Rats have often been used to study these hypotheses, but the lack of enterosalivary cycle of nitrate in rats casts doubt on the relevance of this animal model to predict nitroso- and heme-associated human colon carcinogenesis. The present study was thus designed to clarify whether a nitrite intake that mimics the enterosalivary cycle can modulate hemeinduced nitrosation and fat peroxidation. This study shows that, in contrast with the starting hypothesis, drinking water added with nitrite to mimic the salivary nitrite content did not change the effect of hemoglobin on biochemicalmarkers linked to colon carcinogenesis, notably lipid peroxidation and cytotoxic activity in the colon of rat. However, ingested sodium nitrite increased fecal nitrosocompounds level, but their fecal concentration and their nature (iron-nitrosyl) would probably not be associated with an increased risk of cancer.We thus suggest that the rat model could be relevant for study the effect of red meat on colon carcinogenesis, in spite of the lack of nitrite in the saliva of rats.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/31353
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
Publisher	Taylor & Francis
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